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Article

Detemplated and Pillared 2-Dimensional Zeolite ZSM-55 with Ferrierite Layer Topology as a Carrier for Drugs

Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland
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Author to whom correspondence should be addressed.
Molecules 2020, 25(15), 3501; https://doi.org/10.3390/molecules25153501
Received: 8 July 2020 / Revised: 22 July 2020 / Accepted: 29 July 2020 / Published: 31 July 2020
(This article belongs to the Special Issue Zeolites and Mesoporous Materials: Properties and Applications)
The present studies were conducted to show the potential of 2D zeolites as effective and non-toxic carriers of drugs. Layered zeolites exhibit adjustable interlayer porosity which can be exploited for controlled drug delivery allowing detailed investigation of the drug release because the structure of the carrier is known exactly. This study was conducted with model drugs ciprofloxacin and piracetam, and ZSM-55 with ca 1 nm thick layers, in detemplated and pillared forms. The release profiles differed from the commercial, crystalline forms of drugs—the release rate increased for ciprofloxacin and decreased for piracetam. To understand the dissolution mechanisms the release data were fitted to Korsmeyer-Peppas equation, showing Fickian (for pillared) and anomalous (for detemplated sample) transport. FT-IR studies showed that strong interaction carrier-drug may be responsible for the modified, slowed down release of piracetam while better solubility and faster release of ciprofloxacin was attributed to formation of the protonated form resulting in weaker interaction with the zeolite than in the pure crystalline form. Two independent tests on L929 mice fibroblasts (ToxiLight and PrestoBlue) showed that ZSM-55, in moderate concentrations may be safely used as a carrier of drug molecules, not having negative effect on the cells viability or proliferation rate. View Full-Text
Keywords: 2D zeolites; ZSM-55; drug delivery; modified release; piracetam; ciprofloxacin 2D zeolites; ZSM-55; drug delivery; modified release; piracetam; ciprofloxacin
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MDPI and ACS Style

Strzempek, W.; Korzeniowska, A.; Kowalczyk, A.; Roth, W.J.; Gil, B. Detemplated and Pillared 2-Dimensional Zeolite ZSM-55 with Ferrierite Layer Topology as a Carrier for Drugs. Molecules 2020, 25, 3501. https://doi.org/10.3390/molecules25153501

AMA Style

Strzempek W, Korzeniowska A, Kowalczyk A, Roth WJ, Gil B. Detemplated and Pillared 2-Dimensional Zeolite ZSM-55 with Ferrierite Layer Topology as a Carrier for Drugs. Molecules. 2020; 25(15):3501. https://doi.org/10.3390/molecules25153501

Chicago/Turabian Style

Strzempek, Weronika, Aleksandra Korzeniowska, Andrzej Kowalczyk, Wieslaw J. Roth, and Barbara Gil. 2020. "Detemplated and Pillared 2-Dimensional Zeolite ZSM-55 with Ferrierite Layer Topology as a Carrier for Drugs" Molecules 25, no. 15: 3501. https://doi.org/10.3390/molecules25153501

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