Hydrogels for the Delivery of Plant-Derived (Poly)Phenols
Abstract
:1. Introduction
2. Potential Biomedical Applications of (Poly)Phenols Loaded-Hydrogels
2.1. Skin and Epithelial Diseases
2.1.1. Skin Wound Healing
2.1.2. Epithelial Pathologies
2.1.3. Epithelial Cancer
2.2. Injectable and Targeted Hydrogels
2.3. Hydrogels for Oral and Systemic Administration
3. Hydrogels Projected for Topical Applications
3.1. Quercetin-Containing Hydrogels
3.2. Hydrogels Containing Other Flavonoids
3.3. Hydrogels Containing Phenols with Trans-Cinnamic Acid Skeleton
3.4. Thymol-Containing Hydrogels
3.5. Plant Extract-Containing Hydrogels
4. Injectable Hydrogels
5. Hydrogels Projected for Oral and Systemic Administration.
5.1. Quercetin-Containing Hydrogels
5.2. Hydrogels Containing other (Poly)Phenols
6. Conclusions
Funding
Acknowledgments
Conflicts of Interest
References
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Compound | System | Disease | Experimental Model | Reference | |
---|---|---|---|---|---|
In Vitro and Ex Vivo Models | In Vivo Models | ||||
Skin Wound Healing | |||||
RU | Carbopol Ultrez® 10 NF HG | Skin wound healing | Skin wounds in Wistar rats | [24] | |
RU | CS-PEG-TY in presence of HRP and H2O2 | Injectable wound dressing for skin wounds | Biocompatibility on L929 mouse fibroblasts | Skin wounds in Sprague Dawley rats | [25] |
CGA | Carbopol 940 HG | Skin wound healing | Biocompatibility on L929 mouse fibroblasts | Skin wounds in Swiss mice | [26] |
Q | Carbopol HG | Skin wound healing | Skin wounds in Sprague Dawley rats | [27] | |
FA | Carbopol 980 HG | Diabetic wound healing | Skin wounds in streptozotocin-diabetic Wistar rats | [28] | |
OPC | Light-responsive collagen-based HG | Wound healing | Regenerative capability on HUVECs and human dermal fibroblasts (HDFs) | Skin wounds in streptozocin-diabetic C57BL/6 mice | [29] |
Equisetum pyramidales hoots extracts | Carbopol HG | Wound healing | Skin wounds in Wistar rats | [30] | |
Passiflora edulis Sims leaves extracts | CS-HG | Wound healing | Biocompatibility on L929 mouse fibroblasts | Skin wounds in alloxan- diabetic Wistar rats | [31] |
Q, GFs and 1-bromoperfluorooctane | Carbopol 981 HG | Diabetic wound healing | Biocompatibility on HaCaT human keratinocytes and CCD-986sk human fibroblasts | Skin wounds in streptozotocin-diabetic C57BL/6 mice | [32] |
Q and OA | HA-based nano-HG | Diabetic wound healing | Patients with diabetic foot ulcers | [33] | |
Thymol | BCT-HG | Wound healing | Antimicrobial activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae; Biocompatibility on NIH 3T3 mouse fibroblasts | Wistar rats bearing third degree burn wounds | [34] |
Skin Permeation | |||||
Q and RU | Ceramide liposomes incorporated into cellulose HG using ECH as cross-linking agent | Improvement of drug skin permeation | Skin permeation study on ICR hairy albino mouse skin | [13] | |
NR | pH-responsive cl-CMC-g-pHEA | Improvement of drug skin permeation | Biocompatibility on HaCaT cells; Skin permeation study on hairless mouse skin | [14] | |
LQG and LQ | Ceramide Liposomes incorporated into cellulose HG | Improvement of drug skin permeation | Skin permeation study on dorsal skin of ICR hairy albino mice | [15] | |
FA | NP700 HG | Improvement of drug skin permeation | Skin permeation test on hairless mouse skin | [16] | |
SB and pomegranate oil | Pemulen® TR2 HG system containing pomegranate oil-based nanocapsules | Improvement of drug skin permeation | Skin permeation study on human skin | [35] | |
SB | Carbopol 940 HG | Improvement of drug skin permeation | Skin diffusion study on human cadaver skin | [36] | |
LT | pH and temperature sensitive poly (N-isopropylacrylamide)/HA-based HG | Improvement of drug skin permeation | Skin permeation study on micropig dorsal skin | [37] | |
SB | Thermo-responsive hydrogels based on triblock co-polymers (PolyGelTM) | Improvement of drug skin permeation | Skin permeation study on mouse skin | [38] | |
Epithelial Pathologies | |||||
SB and pomegranate oil | Pemulen® TR2 HG system containing pomegranate oil-based nanocapsules | Irritant contact dermatitis | Croton oil-induced ear edema in Swiss mice; Cutaneous safety in humans | [35] | |
SB | Carbopol 940 HG | Irritant contact dermatitis | Skin irritancy in White New Zealand rabbits; Dinitrochlorobenzene - induced ICD in BALB/c mice | [36] | |
Achyrocline satureioides inflorescences extracts | Carbopol® Ultrez 20 HG | UVA/UVB radiation-induced skin damage | UVA/UVB light-induced oxidative stress on porcine ears skin | [39] | |
FA | Thermosensitive CS/G/GP-HG | Corneal wound healing | H2O2-induced oxidative stress in rabbit corneal epithelial CCL-60 cells | Corneal alkali burn in New Zealand albino rabbits | [40] |
LT | pH and temperature sensitive poly (N-isopropylacrylamide)/HA-based HG | Psoriasis | Cytotoxicity assays on HaCaT human keratinocytes | [37] | |
CA | Cyclodextrin-based HG | Epithelial infections | Antibacterial activity against Staphylococcus epidermidis, Staphylococcus aureus and Klebsiella pneumonia; Proliferation study on NIH 3T3 mouse fibroblasts | [41] | |
Q | CHGZ-HGs | Skin and epithelial infections | Activity against Staphylococcus aureus and Trichophyton rubrum; Biocompatibility on L929 murine fibroblasts | [42] | |
Thymol | CS-HG | Periodontal diseases | Biocompatibility on NIH 3T3 mouse fibroblasts Antibacterial activity against Streptococcus mutans and Staphylococcus aureus | [43] | |
Licorice (Glycyrrhiza glabra) extracts | Tragacanth gum based HG | Recurrent aphthous stomatitis | Patients with aphthous ulcers | [44] | |
Epithelial Cancer | |||||
OPC | Light-responsive collagen-based HG | Melanoma | B16F10 murine melanoma cells | Photothermal therapy in Balb/c mice bearing B16F10 cell tumor | [29] |
Q | CHGZ-HGs | Skin cancer | Human skin carcinoma A431 cells | [42] | |
SB (also in combination with doxorubicin) | Thermo-responsive HG based on triblock co-polymers (PolyGelTM) | Melanoma | B16-F10 murine melanoma cells | [38] | |
EA, EGCG, TA, NDGA, RT, RA, and CMA | PEG-HG | Oral cancer | Human oral cancer CAL-27 cells | [45] | |
Injectable and Targeted Hydrogels | |||||
FA | Thermosensitive CS/G/GP-HG | Secondary brain injury | H2O2-induced oxidative stress in Neuro-2a cells | [46] | |
FA | Thermosensitive CS/G/GP-HG | Intervertebral disc degeneration | H2O2-induced oxidative stress in nucleus pulposus cells from New Zealand rabbits | [47] | |
Q | Thermosensitive hydrogel based on mPEG-PA-HG | Osteoarthritis | Human chondrocytes from patients undergone knee arthroplasty | Rats undergone anterior cruciate ligament transection | [48] |
FA | Thermosensitive CS/G/HG | Cardiovascular diseases | Cisd2-deficient (Cisd2−/−) cardiomyocytes and cardiac tissue of Cisd2 knockout mice | Biocompatibility in subcutaneously injected New Zealand albino rabbits and intramyocardially injected Cisd2 deficient (Cisd2−/−) and wild-type (Cisd2+/+)] rats | [49] |
Q (also in combination with temozolide) | HA-HG | Glioblastoma multiforme | Human glioblastoma A172 and T98MG cells | [50] | |
Q (also in combination with everolimus) | HA-HG | Hormone-responsive human breast cancer | Human breast cancer MCF7 cells | [51] | |
Q (also in combination with SNS-314) | HA-HG | Medullary and papillary human thyroid cancer | Human medullary and papillary cancer thyroid B-CPAP and TT cells; Biocompatibility on NIH 3T3 mouse fibroblasts | [52] | |
Hydrogels for Oral and Systemic Administration | |||||
APG | pH-sensitive gellan gum HGs | Oral delivery system for the controlled release of hydrophobic molecules | Drug release in different pH environments | [53] | |
GTP | Poly electrolyte complex HG | Oral delivery | Media simulating the gastric and the intestinal tracts | [54] | |
RU | pH-sensitive poly(starch/acrylic acid) HG | Ulcerative colitis | Dextran sulphate sodium-induced colitis in Wistar rats | [55] | |
EGCG | Polyphenol-binding amyloid fibrils self-assemble into reversible HGs | Infection of small intestine | Antibacterial activity against Listeria monocytogenes, methicillin resistant Staphylococcus aureus, Streptococcus oralis, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa; Biocompatibility on human colonic epithelial cells | [56] | |
RU and 5-FU | pH-responsive Zein-co-acrylic acid HGs | Anticancer activity | Breast cancer MDA-MB-231and MCF-7 cells | [57] | |
EGCG and CU | HA-HG | Alzheimer’s disease | Human neuroblastoma SH-SY5Y cells | [58] |
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Share and Cite
Micale, N.; Citarella, A.; Molonia, M.S.; Speciale, A.; Cimino, F.; Saija, A.; Cristani, M. Hydrogels for the Delivery of Plant-Derived (Poly)Phenols. Molecules 2020, 25, 3254. https://doi.org/10.3390/molecules25143254
Micale N, Citarella A, Molonia MS, Speciale A, Cimino F, Saija A, Cristani M. Hydrogels for the Delivery of Plant-Derived (Poly)Phenols. Molecules. 2020; 25(14):3254. https://doi.org/10.3390/molecules25143254
Chicago/Turabian StyleMicale, Nicola, Andrea Citarella, Maria Sofia Molonia, Antonio Speciale, Francesco Cimino, Antonella Saija, and Mariateresa Cristani. 2020. "Hydrogels for the Delivery of Plant-Derived (Poly)Phenols" Molecules 25, no. 14: 3254. https://doi.org/10.3390/molecules25143254