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Open AccessArticle

Synthesis, Redox Properties and Antibacterial Activity of Hindered Phenols Linked to Heterocycles

Department of organic chemistry and petroleum chemistry, Gubkin Russian State University of Oil and Gas, Leninsky av. 65, 119991 Moscow, Russia
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Academic Editors: Paola Di Donato and Brigida Silvestri
Molecules 2020, 25(10), 2370; https://doi.org/10.3390/molecules25102370
Received: 21 April 2020 / Revised: 13 May 2020 / Accepted: 19 May 2020 / Published: 20 May 2020
A series of benzotriazole, cyclic amides and pyrimidine derivatives, containing 2,6-di-tert-butyl-phenol fragments, were synthesized. The redox properties of obtained compounds were studied using the cyclic voltammetry on a platinum electrode in acetonitrile. The oxidation potentials of all substances were comparable to those of BHT. The obtained compounds were tested for their antibacterial activity, and N-(2-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-oxoethyl)isatin (32 μg/mL) exerted good activity against Staphylococcus aureus. View Full-Text
Keywords: hindered phenols; heterocycles; antioxidants; antibacterial activity hindered phenols; heterocycles; antioxidants; antibacterial activity
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Koshelev, V.N.; Primerova, O.V.; Vorobyev, S.V.; Ivanova, L.V. Synthesis, Redox Properties and Antibacterial Activity of Hindered Phenols Linked to Heterocycles. Molecules 2020, 25, 2370.

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