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Recent Advances in Polymer Nanomaterials for Drug Delivery of Adjuvants in Colorectal Cancer Treatment: A Scientific-Technological Analysis and Review

1
School of Engineering, Universidad Pontificia Bolivariana, Circular 1 # 70-01, Medellín 050031, Colombia
2
School of Health Sciences, Universidad Pontificia Bolivariana, Calle 78 B # 72 A-109, Medellín 050034, Colombia
3
Medical and Experimental Mycology Group, Corporación para Investigaciones Biológicas, Carrera 72 A # 78 B-141, Medellín 050034, Colombia
*
Author to whom correspondence should be addressed.
Academic Editors: Carlos A. García-González, Pasquale Del Gaudio and Ricardo Starbird
Molecules 2020, 25(10), 2270; https://doi.org/10.3390/molecules25102270
Received: 19 April 2020 / Revised: 30 April 2020 / Accepted: 1 May 2020 / Published: 12 May 2020
(This article belongs to the Special Issue Biopolymers in Drug Delivery and Regenerative Medicine)
Colorectal cancer (CRC) is the type with the second highest morbidity. Recently, a great number of bioactive compounds and encapsulation techniques have been developed. Thus, this paper aims to review the drug delivery strategies for chemotherapy adjuvant treatments for CRC, including an initial scientific-technological analysis of the papers and patents related to cancer, CRC, and adjuvant treatments. For 2018, a total of 167,366 cancer-related papers and 306,240 patents were found. Adjuvant treatments represented 39.3% of the total CRC patents, indicating the importance of adjuvants in the prognosis of patients. Chemotherapy adjuvants can be divided into two groups, natural and synthetic (5-fluorouracil and derivatives). Both groups can be encapsulated using polymers. Polymer-based drug delivery systems can be classified according to polymer nature. From those, anionic polymers have garnered the most attention, because they are pH responsive. The use of polymers tailors the desorption profile, improving drug bioavailability and enhancing the local treatment of CRC via oral administration. Finally, it can be concluded that antioxidants are emerging compounds that can complement today’s chemotherapy treatments. In the long term, encapsulated antioxidants will replace synthetic drugs and will play an important role in curing CRC. View Full-Text
Keywords: colorectal cancer; antioxidants; 5-fluorouracil; polymer nanomaterials; nanocapsules; chemotherapy colorectal cancer; antioxidants; 5-fluorouracil; polymer nanomaterials; nanocapsules; chemotherapy
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Osorio, M.; Martinez, E.; Naranjo, T.; Castro, C. Recent Advances in Polymer Nanomaterials for Drug Delivery of Adjuvants in Colorectal Cancer Treatment: A Scientific-Technological Analysis and Review. Molecules 2020, 25, 2270.

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