A Review on Daphnane-Type Diterpenoids and Their Bioactive Studies
AbstractNatural daphnane diterpenoids, mainly distributed in plants of the Thymelaeaceae and Euphorbiaceae families, usually include a 5/7/6-tricyclic ring system with poly-hydroxyl groups located at C-3, C-4, C-5, C-9, C-13, C-14, or C-20, while some special types have a characteristic orthoester motif triaxially connectedat C-9, C-13, and C-14. The daphnane-type diterpenoids can be classified into five types: 6-epoxy daphnane diterpenoids, resiniferonoids, genkwanines, 1-alkyldaphnanes and rediocides, based on the oxygen-containing functions at rings B and C, as well as the substitution pattern of ring A. Up to now, nearly 200 daphnane-type diterpenoids have been isolated and elucidated from the Thymelaeaceae and Euphorbiaceae families. In-vitro and in-vivo experiments of these compounds have shown that they possess a wide range of biological activities, including anti-HIV, anti-cancer, anti-leukemic, neurotrophic, pesticidal and cytotoxic effects. A comprehensive account of the structural diversity is given in this review, along with the cytotoxic activities of daphnane-type diterpenoids, up to April 2019. View Full-Text
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Jin, Y.-X.; Shi, L.-L.; Zhang, D.-P.; Wei, H.-Y.; Si, Y.; Ma, G.-X.; Zhang, J. A Review on Daphnane-Type Diterpenoids and Their Bioactive Studies. Molecules 2019, 24, 1842.
Jin Y-X, Shi L-L, Zhang D-P, Wei H-Y, Si Y, Ma G-X, Zhang J. A Review on Daphnane-Type Diterpenoids and Their Bioactive Studies. Molecules. 2019; 24(9):1842.Chicago/Turabian Style
Jin, Yue-Xian; Shi, Lei-Ling; Zhang, Da-Peng; Wei, Hong-Yan; Si, Yuan; Ma, Guo-Xu; Zhang, Jing. 2019. "A Review on Daphnane-Type Diterpenoids and Their Bioactive Studies." Molecules 24, no. 9: 1842.
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