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Open AccessReview

A Review on Daphnane-Type Diterpenoids and Their Bioactive Studies

by Yue-Xian Jin 1,2,†, Lei-Ling Shi 3,†, Da-Peng Zhang 4, Hong-Yan Wei 3, Yuan Si 1, Guo-Xu Ma 2,3,* and Jing Zhang 1,*
1
College of Chinese Medicine Material, Jilin Agricultural University, Changchun 130118, China
2
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and PekingUnion Medical College, Beijing 100193, China
3
Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi 830002, China
4
College of Life Science and Technology, Xinjiang University, Urumqi 830046, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2019, 24(9), 1842; https://doi.org/10.3390/molecules24091842
Received: 16 April 2019 / Revised: 6 May 2019 / Accepted: 7 May 2019 / Published: 13 May 2019
(This article belongs to the Collection Bioactive Compounds)
Natural daphnane diterpenoids, mainly distributed in plants of the Thymelaeaceae and Euphorbiaceae families, usually include a 5/7/6-tricyclic ring system with poly-hydroxyl groups located at C-3, C-4, C-5, C-9, C-13, C-14, or C-20, while some special types have a characteristic orthoester motif triaxially connectedat C-9, C-13, and C-14. The daphnane-type diterpenoids can be classified into five types: 6-epoxy daphnane diterpenoids, resiniferonoids, genkwanines, 1-alkyldaphnanes and rediocides, based on the oxygen-containing functions at rings B and C, as well as the substitution pattern of ring A. Up to now, nearly 200 daphnane-type diterpenoids have been isolated and elucidated from the Thymelaeaceae and Euphorbiaceae families. In-vitro and in-vivo experiments of these compounds have shown that they possess a wide range of biological activities, including anti-HIV, anti-cancer, anti-leukemic, neurotrophic, pesticidal and cytotoxic effects. A comprehensive account of the structural diversity is given in this review, along with the cytotoxic activities of daphnane-type diterpenoids, up to April 2019. View Full-Text
Keywords: daphnane; diterpenoid; cytotoxic activities daphnane; diterpenoid; cytotoxic activities
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MDPI and ACS Style

Jin, Y.-X.; Shi, L.-L.; Zhang, D.-P.; Wei, H.-Y.; Si, Y.; Ma, G.-X.; Zhang, J. A Review on Daphnane-Type Diterpenoids and Their Bioactive Studies. Molecules 2019, 24, 1842.

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