Next Article in Journal
1H-NMR Metabolomics Analysis of the Effects of Sulfated Polysaccharides from Masson Pine Pollen in RAW264.7 Macrophage Cells
Next Article in Special Issue
Anti-Inflammatory Compounds from Atractylodes macrocephala
Previous Article in Journal
The Role of Astragaloside IV against Cerebral Ischemia/Reperfusion Injury: Suppression of Apoptosis via Promotion of P62-LC3-Autophagy
Previous Article in Special Issue
Phenolic Profile and Bioactive Properties of Carissa macrocarpa (Eckl.) A.DC.: An In Vitro Comparative Study between Leaves, Stems, and Flowers
Article Menu
Issue 9 (May-1) cover image

Export Article

Open AccessReview

A Review on Daphnane-Type Diterpenoids and Their Bioactive Studies

1
College of Chinese Medicine Material, Jilin Agricultural University, Changchun 130118, China
2
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and PekingUnion Medical College, Beijing 100193, China
3
Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi 830002, China
4
College of Life Science and Technology, Xinjiang University, Urumqi 830046, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2019, 24(9), 1842; https://doi.org/10.3390/molecules24091842
Received: 16 April 2019 / Revised: 6 May 2019 / Accepted: 7 May 2019 / Published: 13 May 2019
(This article belongs to the Collection Bioactive Compounds)
  |  
PDF [1965 KB, uploaded 13 May 2019]
  |     |  

Abstract

Natural daphnane diterpenoids, mainly distributed in plants of the Thymelaeaceae and Euphorbiaceae families, usually include a 5/7/6-tricyclic ring system with poly-hydroxyl groups located at C-3, C-4, C-5, C-9, C-13, C-14, or C-20, while some special types have a characteristic orthoester motif triaxially connectedat C-9, C-13, and C-14. The daphnane-type diterpenoids can be classified into five types: 6-epoxy daphnane diterpenoids, resiniferonoids, genkwanines, 1-alkyldaphnanes and rediocides, based on the oxygen-containing functions at rings B and C, as well as the substitution pattern of ring A. Up to now, nearly 200 daphnane-type diterpenoids have been isolated and elucidated from the Thymelaeaceae and Euphorbiaceae families. In-vitro and in-vivo experiments of these compounds have shown that they possess a wide range of biological activities, including anti-HIV, anti-cancer, anti-leukemic, neurotrophic, pesticidal and cytotoxic effects. A comprehensive account of the structural diversity is given in this review, along with the cytotoxic activities of daphnane-type diterpenoids, up to April 2019. View Full-Text
Keywords: daphnane; diterpenoid; cytotoxic activities daphnane; diterpenoid; cytotoxic activities
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Jin, Y.-X.; Shi, L.-L.; Zhang, D.-P.; Wei, H.-Y.; Si, Y.; Ma, G.-X.; Zhang, J. A Review on Daphnane-Type Diterpenoids and Their Bioactive Studies. Molecules 2019, 24, 1842.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top