Anti-Inflammatory Compounds from Atractylodes macrocephala
AbstractIn relation to anti-inflammatory agents from medicinal plants, we have isolated three compounds from Atractylodes macrocephala; 1, 2-[(2E)-3,7-dimethyl-2,6-octadienyl]-6-methyl-2, 5-cyclohexadiene-1, 4-dione; 2, 1-acetoxy-tetradeca-6E,12E-diene-8, 10-diyne-3-ol; 3, 1,3-diacetoxy-tetradeca-6E, 12E-diene-8, 10-diyne. Compounds 1–3 showed concentration-dependent inhibitory effects on production of nitric oxide (NO) and prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. Western blotting and RT-PCR analyses demonstrated that compounds 1–3 suppressed the protein and mRNA levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Furthermore, compounds 1–3 inhibited transcriptional activity of nuclear factor-κB (NF-κB) and nuclear translocation of NF-κB in LPS-activated RAW 264.7 cells. The most active compound among them, compound 1, could reduce the mRNA levels of pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α) and suppress the phosphorylation of MAPK including p38, JNK, and ERK1/2. Taken together, these results suggest that compounds 1–3 from A. macrocephala can be therapeutic candidates to treat inflammatory diseases. View Full-Text
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Jeong, D.; Dong, G.-Z.; Lee, H.J.; Ryu, J.-H. Anti-Inflammatory Compounds from Atractylodes macrocephala. Molecules 2019, 24, 1859.
Jeong D, Dong G-Z, Lee HJ, Ryu J-H. Anti-Inflammatory Compounds from Atractylodes macrocephala. Molecules. 2019; 24(10):1859.Chicago/Turabian Style
Jeong, Dawoon; Dong, Guang-zhi; Lee, Hwa J.; Ryu, Jae-Ha. 2019. "Anti-Inflammatory Compounds from Atractylodes macrocephala." Molecules 24, no. 10: 1859.
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