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Open AccessCommunication

Anti-Inflammatory Compounds from Atractylodes macrocephala

1
College of Pharmacy, Sookmyung Women’s University, Seoul 04310, Korea
2
School of Industrial Bio-Pharmaceutical Science, Semyung University, Jecheon, Chungbuk 27136, Korea
*
Author to whom correspondence should be addressed.
Academic Editors: Isabel Ferreira and Nancy D. Turner
Molecules 2019, 24(10), 1859; https://doi.org/10.3390/molecules24101859
Received: 22 April 2019 / Revised: 10 May 2019 / Accepted: 13 May 2019 / Published: 14 May 2019
(This article belongs to the Collection Bioactive Compounds)
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Abstract

In relation to anti-inflammatory agents from medicinal plants, we have isolated three compounds from Atractylodes macrocephala; 1, 2-[(2E)-3,7-dimethyl-2,6-octadienyl]-6-methyl-2, 5-cyclohexadiene-1, 4-dione; 2, 1-acetoxy-tetradeca-6E,12E-diene-8, 10-diyne-3-ol; 3, 1,3-diacetoxy-tetradeca-6E, 12E-diene-8, 10-diyne. Compounds 13 showed concentration-dependent inhibitory effects on production of nitric oxide (NO) and prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. Western blotting and RT-PCR analyses demonstrated that compounds 13 suppressed the protein and mRNA levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Furthermore, compounds 13 inhibited transcriptional activity of nuclear factor-κB (NF-κB) and nuclear translocation of NF-κB in LPS-activated RAW 264.7 cells. The most active compound among them, compound 1, could reduce the mRNA levels of pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α) and suppress the phosphorylation of MAPK including p38, JNK, and ERK1/2. Taken together, these results suggest that compounds 13 from A. macrocephala can be therapeutic candidates to treat inflammatory diseases. View Full-Text
Keywords: nitric oxide; prostaglandin E2; inducible nitric oxide synthase; cyclooxygenase-2; nuclear factor-κB; Atractylodes macrocephala nitric oxide; prostaglandin E2; inducible nitric oxide synthase; cyclooxygenase-2; nuclear factor-κB; Atractylodes macrocephala
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Jeong, D.; Dong, G.-Z.; Lee, H.J.; Ryu, J.-H. Anti-Inflammatory Compounds from Atractylodes macrocephala. Molecules 2019, 24, 1859.

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