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α-Ionone Protects Against UVB-Induced Photoaging in Human Dermal Fibroblasts

Department of Food and Nutrition, Brain Korea 21 PLUS Project, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea
Author to whom correspondence should be addressed.
Academic Editors: Francesca Giampieri and Derek McPhee
Molecules 2019, 24(9), 1804;
Received: 3 April 2019 / Revised: 3 May 2019 / Accepted: 7 May 2019 / Published: 9 May 2019
PDF [3292 KB, uploaded 9 May 2019]


Ultraviolet (UV) light-induced wrinkle formation is a major dermatological problem and is associated with alteration in collagen. Here, we investigated the potential of α-ionone, a naturally occurring aromatic compound, in regulation of UVB-induced photoaging in human Hs68 dermal fibroblasts and identified the mechanisms involved. We found that in human dermal fibroblasts, α-ionone inhibited UVB-induced loss of collagen. α-Ionone upregulated the molecules participating in the TGF-β–SMAD pathway (TGF-β1, phospho-SMAD2/3, Col1A1, and Col1A2), but downregulated the molecules involved in the MAPK–AP-1 signaling pathway (phospho-p38, phospho-JNK, phospho-ERK, phospho-c-Fos, phospho-c-Jun, MMP1, MMP3, and MMP9), in human dermal fibroblasts. α-Ionone treatment also increased hyaluronic acid contents, and this effect was accompanied by an upregulation of mRNA expression of genes (HAS1 and HAS2) involved in hyaluronic acid synthesis. Thus, α-ionone is effective in the prevention of UVB-induced decrease of collagen and hyaluronic acid in human dermal fibroblasts. We propose that α-ionone may prove beneficial for the prevention of UV-induced wrinkle formation and skin damage. View Full-Text
Keywords: α-ionone; dermal fibroblasts; photoaging; collagen; hyaluronic acid α-ionone; dermal fibroblasts; photoaging; collagen; hyaluronic acid

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Tong, T.; Park, J.; Moon, Y.; Kang, W.; Park, T. α-Ionone Protects Against UVB-Induced Photoaging in Human Dermal Fibroblasts. Molecules 2019, 24, 1804.

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