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Open AccessFeature PaperReview

Red Beetroot and Betalains as Cancer Chemopreventative Agents

by John F. Lechner *,†,‡ and Gary D. Stoner
Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA
Author to whom correspondence should be addressed.
Retired, former affiliation: Department of Medicine, Division of Medical Oncology, Ohio State University, Columbus, OH 43210, USA.
Current address—3849 Jester Ct. NW, Olympia, WA 98502, USA.
Academic Editor: Derek J. McPhee
Molecules 2019, 24(8), 1602;
Received: 8 March 2019 / Revised: 19 April 2019 / Accepted: 20 April 2019 / Published: 23 April 2019
(This article belongs to the Special Issue Natural Products for Cancer Chemoprevention)
Carcinogenesis is the process whereby a normal cell is transformed into a neoplastic cell. This action involves several steps starting with initiation and followed by promotion and progression. Driving these stages are oxidative stress and inflammation, which in turn encompasses a myriad of aberrant gene expressions, both within the transforming cell population and the cells within the surrounding lesion. Chemoprevention of cancer with bioreactive foods or their extracted/purified components occurs via normalizing these inappropriate gene activities. Various foods/agents have been shown to affect different gene expressions. In this review, we discuss whereby the chemoprevention activities of the red beetroot itself may disrupt carcinogenesis and the activities of the water-soluble betalains extracted from the plant. View Full-Text
Keywords: beetroot; betanins; cancer chemoprevention; anti-oxidant; inflammation; apoptosis beetroot; betanins; cancer chemoprevention; anti-oxidant; inflammation; apoptosis
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Lechner, J.F.; Stoner, G.D. Red Beetroot and Betalains as Cancer Chemopreventative Agents. Molecules 2019, 24, 1602.

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