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Antiviral Activities of Silymarin and Derivatives

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Department of Microbiology & Immunology, Dalhousie University, Halifax, NS B3H 4R2, Canada
International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Author to whom correspondence should be addressed.
Academic Editor: Dominique Delmas
Molecules 2019, 24(8), 1552;
Received: 31 March 2019 / Revised: 16 April 2019 / Accepted: 17 April 2019 / Published: 19 April 2019
(This article belongs to the Special Issue Silymarin and Derivatives: From Biosynthesis to Health Benefits)
PDF [437 KB, uploaded 19 April 2019]


Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-inflammatory, and hepatoprotective functions. Recent studies have also documented the antiviral activities of silymarin and its derivatives against several viruses, including the flaviviruses (hepatitis C virus and dengue virus), togaviruses (Chikungunya virus and Mayaro virus), influenza virus, human immunodeficiency virus, and hepatitis B virus. This review will describe some of the latest preclinical and clinical studies detailing the antiviral profiles of silymarin and its derivatives, and discuss their relevance for antiviral drug development. View Full-Text
Keywords: silymarin; flavonolignans; antiviral; drug development silymarin; flavonolignans; antiviral; drug development

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Liu, C.-H.; Jassey, A.; Hsu, H.-Y.; Lin, L.-T. Antiviral Activities of Silymarin and Derivatives. Molecules 2019, 24, 1552.

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