Anti-Mycobacterium tuberculosis Terpenoids from Resina Commiphora
AbstractFour new compounds including two new sesquiterpenoid dimers, commiphoroids E (1) and F (2), a new triterpenoid (3), and a new sesquiterpenoid (4), along with three known terpenoids (5−7) were isolated from Resina Commiphora, whose structures were identified by NMR spectra, HRESIMS, and X-ray diffraction analysis. Compounds 1 and 2 both bear an O-bridge ring and feature a plausible [4 + 2] Diels–Alder cycloaddition reaction. Antimycobacterial activities show that all the tested compounds (200 μM) could inhibit the growth of both sensitive and clinically multi-drug resistant (MDR) isolated strains. In addition, cellular toxicity of the isolates against human cancer cells and THP-1 monocyte cells was examined. View Full-Text
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Zhu, C.-Z.; Hu, B.-Y.; Liu, J.-W.; Cai, Y.; Chen, X.-C.; Qin, D.-P.; Cheng, Y.-X.; Zhang, Z.-D. Anti-Mycobacterium tuberculosis Terpenoids from Resina Commiphora. Molecules 2019, 24, 1475.
Zhu C-Z, Hu B-Y, Liu J-W, Cai Y, Chen X-C, Qin D-P, Cheng Y-X, Zhang Z-D. Anti-Mycobacterium tuberculosis Terpenoids from Resina Commiphora. Molecules. 2019; 24(8):1475.Chicago/Turabian Style
Zhu, Chuan-Zhi; Hu, Bin-Yuan; Liu, Jia-Wang; Cai, Yi; Chen, Xin-Chun; Qin, Da-Peng; Cheng, Yong-Xian; Zhang, Zong-De. 2019. "Anti-Mycobacterium tuberculosis Terpenoids from Resina Commiphora." Molecules 24, no. 8: 1475.
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