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Molecules 2019, 24(8), 1475; https://doi.org/10.3390/molecules24081475

Anti-Mycobacterium tuberculosis Terpenoids from Resina Commiphora

1
Laboratory of Molecular Biology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
2
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 5 March 2019 / Revised: 4 April 2019 / Accepted: 12 April 2019 / Published: 15 April 2019
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Four new compounds including two new sesquiterpenoid dimers, commiphoroids E (1) and F (2), a new triterpenoid (3), and a new sesquiterpenoid (4), along with three known terpenoids (57) were isolated from Resina Commiphora, whose structures were identified by NMR spectra, HRESIMS, and X-ray diffraction analysis. Compounds 1 and 2 both bear an O-bridge ring and feature a plausible [4 + 2] Diels–Alder cycloaddition reaction. Antimycobacterial activities show that all the tested compounds (200 μM) could inhibit the growth of both sensitive and clinically multi-drug resistant (MDR) isolated strains. In addition, cellular toxicity of the isolates against human cancer cells and THP-1 monocyte cells was examined. View Full-Text
Keywords: Resina Commiphora; plant resins; terpenoids; anti-Mycobacterium tuberculosis Resina Commiphora; plant resins; terpenoids; anti-Mycobacterium tuberculosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Zhu, C.-Z.; Hu, B.-Y.; Liu, J.-W.; Cai, Y.; Chen, X.-C.; Qin, D.-P.; Cheng, Y.-X.; Zhang, Z.-D. Anti-Mycobacterium tuberculosis Terpenoids from Resina Commiphora. Molecules 2019, 24, 1475.

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