Investigation of 8-Aza-7-Deaza Purine Nucleoside Derivatives
AbstractGlycosylation of 6-amino-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine and its iodo- and bromo- analogues with the protected ribofuranose and 2′-deoxyribofuranose under different conditions resulted in the synthesis of N9- and N8-glycosylated purine nucleosides. Five key intermediate nucleosides, having 6-methoxy, 7-iodo, and 2-bromo groups, were further derivatized to 23 final 8-aza-7-deazapurine nucleoside derivatives. The structures of N9- and N8-glycosylated products were assigned based on UV and NMR spectra. HMBC analysis of 2D NMR spectra and X-ray crystallographic studies of the representative compounds unambiguously verified the connection of ribose ring to N9- or N8-position of the purine ring. The anticancer activity of these new compounds was evaluated. View Full-Text
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Ren, H.; An, H.; Tao, J. Investigation of 8-Aza-7-Deaza Purine Nucleoside Derivatives. Molecules 2019, 24, 983.
Ren H, An H, Tao J. Investigation of 8-Aza-7-Deaza Purine Nucleoside Derivatives. Molecules. 2019; 24(5):983.Chicago/Turabian Style
Ren, Hang; An, Haoyun; Tao, Jingchao. 2019. "Investigation of 8-Aza-7-Deaza Purine Nucleoside Derivatives." Molecules 24, no. 5: 983.
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