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Molecules 2019, 24(5), 918; https://doi.org/10.3390/molecules24050918

Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System

1,†
,
1,†
,
2,3,‡
and
1,*,‡
1
Department of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary
2
Department of Immunology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary
3
HCEMM Nonprofit Ltd., 6720 Szeged, Hungary
*
Author to whom correspondence should be addressed.
These authors contributed equally.
These authors contributed equally.
Received: 12 February 2019 / Revised: 28 February 2019 / Accepted: 1 March 2019 / Published: 6 March 2019
(This article belongs to the Special Issue Emerging Topics in (Endo)Cannabinoid Signalling)
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Abstract

The endocannabinoid system (ECS) has lately been proven to be an important, multifaceted homeostatic regulator, which influences a wide-variety of physiological processes all over the body. Its members, the endocannabinoids (eCBs; e.g., anandamide), the eCB-responsive receptors (e.g., CB1, CB2), as well as the complex enzyme and transporter apparatus involved in the metabolism of the ligands were shown to be expressed in several tissues, including the skin. Although the best studied functions over the ECS are related to the central nervous system and to immune processes, experimental efforts over the last two decades have unambiguously confirmed that cutaneous cannabinoid (“c[ut]annabinoid”) signaling is deeply involved in the maintenance of skin homeostasis, barrier formation and regeneration, and its dysregulation was implicated to contribute to several highly prevalent diseases and disorders, e.g., atopic dermatitis, psoriasis, scleroderma, acne, hair growth and pigmentation disorders, keratin diseases, various tumors, and itch. The current review aims to give an overview of the available skin-relevant endo- and phytocannabinoid literature with a special emphasis on the putative translational potential, and to highlight promising future research directions as well as existing challenges. View Full-Text
Keywords: acne; atopic dermatitis; cannabinoid; fibrosis; hair growth; inflammation; itch; psoriasis; skin; tumor; wound healing acne; atopic dermatitis; cannabinoid; fibrosis; hair growth; inflammation; itch; psoriasis; skin; tumor; wound healing
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Tóth, K.F.; Ádám, D.; Bíró, T.; Oláh, A. Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System. Molecules 2019, 24, 918.

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