Next Article in Journal
Controlled Synthesis of Tb3+/Eu3+ Co-Doped Gd2O3 Phosphors with Enhanced Red Emission
Next Article in Special Issue
Surface Structuring Combined with Chemical Surface Functionalization: An Effective Tool to Manipulate Cell Adhesion
Previous Article in Journal
Evaluation of WBSF, Color, Cooking Loss of Longissimus Lumborum Muscle with Fiber Optic Near-Infrared Spectroscopy (FT-NIR), Depending on Aging Time
Previous Article in Special Issue
Micrometric Wrinkled Patterns Spontaneously Formed on Hydrogel Thin Films via Argon Plasma Exposure
Article Menu
Issue 4 (February-2) cover image

Export Article

Open AccessArticle

Heparinized Polyurethane Surface Via a One-Step Photografting Method

1
National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China
2
School of Medicine, South China University of Technology, Guangzhou 510641, China
3
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
4
Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen, Germany
5
Institute for Polymer Chemistry and Chemical Technology (ITCP), Karlsruhe Institute of Technology (KIT), 76137 Karlsruhe, Germany
6
Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Guillaume Delaittre
Molecules 2019, 24(4), 758; https://doi.org/10.3390/molecules24040758
Received: 6 November 2018 / Revised: 13 February 2019 / Accepted: 14 February 2019 / Published: 20 February 2019
(This article belongs to the Special Issue Chemical Surface Functionalization)
  |  
PDF [3298 KB, uploaded 20 February 2019]
  |  

Abstract

Traditional methods using coupling chemistry for surface grafting of heparin onto polyurethane (PU) are disadvantageous due to their generally low efficiency. In order to overcome this problem, a quick one-step photografting method is proposed here. Three heparin derivatives incorporating 0.21, 0.58, and 0.88 wt% pendant aryl azide groups were immobilized onto PU surfaces, leading to similar grafting densities of 1.07, 1.17, and 1.13 μg/cm2, respectively, yet with increasing densities of anchoring points. The most negatively charged surface and the maximum binding ability towards antithrombin III were found for the heparinized PU with the lowest amount of aryl azide/anchor sites. Furthermore, decreasing the density of anchoring points was found to inhibit platelet adhesion to a larger extent and to prolong plasma recalcification time, prothrombin time, thrombin time, and activated partial thromboplastin time to a larger extent. This was also found to enhance the bioactivity of immobilized heparin from 22.9% for raw heparin to 36.9%. This could be explained by the enhanced molecular mobility of immobilized heparin when it is more loosely anchored to the PU surface, as well as a higher surface charge. View Full-Text
Keywords: catheter; polyurethane; photografting; heparinization; bioactivity catheter; polyurethane; photografting; heparinization; bioactivity
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Liu, Z.; Fang, L.; Delaittre, G.; Ke, Y.; Wu, G. Heparinized Polyurethane Surface Via a One-Step Photografting Method. Molecules 2019, 24, 758.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top