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Open AccessArticle

Heparinized Polyurethane Surface Via a One-Step Photografting Method

by Zhangshuan Liu 1,2, Liming Fang 1,3, Guillaume Delaittre 4,5, Yu Ke 6,* and Gang Wu 1,3,*
National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China
School of Medicine, South China University of Technology, Guangzhou 510641, China
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen, Germany
Institute for Polymer Chemistry and Chemical Technology (ITCP), Karlsruhe Institute of Technology (KIT), 76137 Karlsruhe, Germany
Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China
Authors to whom correspondence should be addressed.
Academic Editor: Guillaume Delaittre
Molecules 2019, 24(4), 758;
Received: 6 November 2018 / Revised: 13 February 2019 / Accepted: 14 February 2019 / Published: 20 February 2019
(This article belongs to the Special Issue Chemical Surface Functionalization)
Traditional methods using coupling chemistry for surface grafting of heparin onto polyurethane (PU) are disadvantageous due to their generally low efficiency. In order to overcome this problem, a quick one-step photografting method is proposed here. Three heparin derivatives incorporating 0.21, 0.58, and 0.88 wt% pendant aryl azide groups were immobilized onto PU surfaces, leading to similar grafting densities of 1.07, 1.17, and 1.13 μg/cm2, respectively, yet with increasing densities of anchoring points. The most negatively charged surface and the maximum binding ability towards antithrombin III were found for the heparinized PU with the lowest amount of aryl azide/anchor sites. Furthermore, decreasing the density of anchoring points was found to inhibit platelet adhesion to a larger extent and to prolong plasma recalcification time, prothrombin time, thrombin time, and activated partial thromboplastin time to a larger extent. This was also found to enhance the bioactivity of immobilized heparin from 22.9% for raw heparin to 36.9%. This could be explained by the enhanced molecular mobility of immobilized heparin when it is more loosely anchored to the PU surface, as well as a higher surface charge. View Full-Text
Keywords: catheter; polyurethane; photografting; heparinization; bioactivity catheter; polyurethane; photografting; heparinization; bioactivity
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MDPI and ACS Style

Liu, Z.; Fang, L.; Delaittre, G.; Ke, Y.; Wu, G. Heparinized Polyurethane Surface Via a One-Step Photografting Method. Molecules 2019, 24, 758.

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