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Endocannabinoid System in the Airways

Department of Pharmacology, Faculty of Pharmacy, Hacettepe University, Ankara 06100, Turkey
Academic Editor: Raffaele Capasso
Molecules 2019, 24(24), 4626; https://doi.org/10.3390/molecules24244626
Received: 13 November 2019 / Revised: 12 December 2019 / Accepted: 15 December 2019 / Published: 17 December 2019
(This article belongs to the Special Issue Research on the Cannabinoid Receptors Pharmacology)
Cannabinoids and the mammalian endocannabinoid system is an important research area of interest and attracted many researchers because of their widespread biological effects. The significant immune-modulatory role of cannabinoids has suggested their therapeutic use in several inflammatory conditions. Airways are prone to environmental irritants and stimulants, and increased inflammation is an important process in most of the respiratory diseases. Therefore, the main strategies for treating airway diseases are suppression of inflammation and producing bronchodilation. The ability of cannabinoids to induce bronchodilation and modify inflammation indicates their importance for airway physiology and pathologies. In this review, the contribution of cannabinoids and the endocannabinoid system in the airways are discussed, and the existing data for their therapeutic use in airway diseases are presented. View Full-Text
Keywords: cannabinoids; endocannabinoids; airway; cannabinoid receptor; fatty acid amide hydrolase; monoacylglycerol lipase cannabinoids; endocannabinoids; airway; cannabinoid receptor; fatty acid amide hydrolase; monoacylglycerol lipase
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Bozkurt, T.E. Endocannabinoid System in the Airways. Molecules 2019, 24, 4626.

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