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Open AccessArticle

The Effect of Ten Essential Oils on Several Cutaneous Drug-Resistant Microorganisms and Their Cyto/Genotoxic and Antioxidant Properties

1
Cancer Research Institute BMC, Slovak Academy of Sciences, Dúbravská cesta 9, 845 05 Bratislava, Slovakia
2
Institute of Molecular Biology, Slovak Academy of Sciences, Dúbravská cesta 21, 84551 Bratislava, Slovakia
3
Department of Genetics, Faculty of Natural Sciences, Comenius, University, Mlynská dolina, 842 15 Bratislava, Slovakia
4
Food Research Institute, National Agricultural and Food Centre, Priemyselná 4, 824 75 Bratislava, Slovakia
*
Author to whom correspondence should be addressed.
Academic Editors: Daniela Rigano and Vincenzo De Feo
Molecules 2019, 24(24), 4570; https://doi.org/10.3390/molecules24244570
Received: 21 September 2019 / Revised: 28 November 2019 / Accepted: 5 December 2019 / Published: 13 December 2019
(This article belongs to the Special Issue Essential Oils as Antimicrobial and Anti-infectious Agents II)
In this study, we determined the antimicrobial activity of ten essential oils (EOs)—oregano, thyme, clove, arborvitae, cassia, lemongrass, melaleuca, eucalyptus, lavender, and clary sage—against drug-resistant microorganisms previously isolated from patients with skin infections. The essential oil compositions were determined using gas chromatography coupled to mass spectrometry (GC/MS). The assayed bacteria included Pseudomonas aeruginosa, Proteus vulgaris, Citrobacter koseri, and Klebsiella pneumoniae. Two drug-resistant yeasts (Candida albicans and Candida parapsilosis) were also involved in our survey. Oregano, thyme, cassia, lemongrass and arborvitae showed very strong antibacterial and antifungal activity against all tested strains. These results show that these essential oils may be effective in preventing the growth of the drug-resistant microorganisms responsible for wound infections. In this study, the genotoxic effects of tested essential oils on healthy human keratinocytes HaCaT were evaluated using the comet assay for the first time. These results revealed that none of the essential oils induced significant DNA damage in vitro after 24 h. Moreover, the treatment of HaCaT cells with essential oils increased the total antioxidant status (TAS) level. The obtained results indicate that EOs could be used as a potential source of safe and potent natural antimicrobial and antioxidant agents in the pharmaceutical and food industries. View Full-Text
Keywords: multi-drug-resistant bacteria; drug-resistant Candida; essential oils; cyto/genotoxic effects; total antioxidant status; human keratinocytes HaCaT multi-drug-resistant bacteria; drug-resistant Candida; essential oils; cyto/genotoxic effects; total antioxidant status; human keratinocytes HaCaT
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Kozics, K.; Bučková, M.; Puškárová, A.; Kalászová, V.; Cabicarová, T.; Pangallo, D. The Effect of Ten Essential Oils on Several Cutaneous Drug-Resistant Microorganisms and Their Cyto/Genotoxic and Antioxidant Properties. Molecules 2019, 24, 4570.

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