Effects of Puerarin on the Ovariectomy-Induced Depressive-Like Behavior in ICR Mice and Its Possible Mechanism of Action

Tantipongpiradet, Ariyawan; Monthakantirat, Orawan; Vipatpakpaiboon, Onchuma; Khampukdee, Charinya; Umehara, Kaoru; Noguchi, Hiroshi; Fujiwara, Hironori; Matsumoto, Kinzo; Sekeroglu, Nazim; Kijjoa, Anake; Chulikhit, Yaowared

doi:10.3390/molecules24244569

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Effects of Puerarin on the Ovariectomy-Induced Depressive-Like Behavior in ICR Mice and Its Possible Mechanism of Action

Ariyawan Tantipongpiradet

¹,

Orawan Monthakantirat

¹,

Onchuma Vipatpakpaiboon

¹,

²,

²,

³,

³,

⁴

^5,*

and

Yaowared Chulikhit

^1,*

Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand

Department of Pharmacognosy, School of Pharmaceutical Sciences, University of Shizuoka, Yada 52-1, Shizuoka-shi, Shizuoka 422-8526, Japan

Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

⁴

Department of Horticulture, Faculty of Agriculture, Killis 7 Aralik University, Killis 79000, Turkey

⁵

ICBAS-Instituto de Ciências Biomédicas Abel Salazar and CIIMAR, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal

Authors to whom correspondence should be addressed.

Molecules 2019, 24(24), 4569; https://doi.org/10.3390/molecules24244569

Received: 23 September 2019 / Revised: 5 December 2019 / Accepted: 11 December 2019 / Published: 13 December 2019

(This article belongs to the Special Issue Selected Papers from the Joint Symposia of MESMAP-5 & ISPBS-5)

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Abstract

Daily treatment of ovariectomized (OVX) ICR mice with puerarin, a glycosyl isoflavone isolated from the root bark of Pueraria candollei var. mirifica, and 17β-estradiol attenuated ovariectomy-induced depression-like behavior, as indicated by a decrease in immobility times in the tail suspension test (TST) and the forced swimming test (FST), an increase in the uterine weight and volume, a decrease in serum corticosterone levels, and dose-dependently normalized the downregulated transcription of the brain-derived neurotrophic factor (BDNF) and estrogen receptor (Erβ and Erα) mRNAs. Like 17β-estradiol, puerarin also inhibited ovariectomy-induced suppression of neurogenesis in the dentate gyrus of the hippocampus (increased the number of doublecortin (DCX)-immunosuppressive cells). These results suggest that puerarin exerts antidepressant-like effects in OVX animals, possibly by attenuating the OVX-induced hyperactivation of the HPA axis and/or normalizing the downregulated transcription of BDNF and ER mRNA in the brain. View Full-Text

Keywords: puerarin; Pueraria candollei var. mirifica; ovariectomy; forced swimming test; tail suspension test; neurogenesis

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Tantipongpiradet, A.; Monthakantirat, O.; Vipatpakpaiboon, O.; Khampukdee, C.; Umehara, K.; Noguchi, H.; Fujiwara, H.; Matsumoto, K.; Sekeroglu, N.; Kijjoa, A.; Chulikhit, Y. Effects of Puerarin on the Ovariectomy-Induced Depressive-Like Behavior in ICR Mice and Its Possible Mechanism of Action. Molecules 2019, 24, 4569. https://doi.org/10.3390/molecules24244569

AMA Style

Tantipongpiradet A, Monthakantirat O, Vipatpakpaiboon O, Khampukdee C, Umehara K, Noguchi H, Fujiwara H, Matsumoto K, Sekeroglu N, Kijjoa A, Chulikhit Y. Effects of Puerarin on the Ovariectomy-Induced Depressive-Like Behavior in ICR Mice and Its Possible Mechanism of Action. Molecules. 2019; 24(24):4569. https://doi.org/10.3390/molecules24244569

Chicago/Turabian Style

Tantipongpiradet, Ariyawan, Orawan Monthakantirat, Onchuma Vipatpakpaiboon, Charinya Khampukdee, Kaoru Umehara, Hiroshi Noguchi, Hironori Fujiwara, Kinzo Matsumoto, Nazim Sekeroglu, Anake Kijjoa, and Yaowared Chulikhit. 2019. "Effects of Puerarin on the Ovariectomy-Induced Depressive-Like Behavior in ICR Mice and Its Possible Mechanism of Action" Molecules 24, no. 24: 4569. https://doi.org/10.3390/molecules24244569

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Effects of Puerarin on the Ovariectomy-Induced Depressive-Like Behavior in ICR Mice and Its Possible Mechanism of Action

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