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Open AccessArticle

Phytochemical Fingerprinting and In Vitro Bioassays of the Ethnomedicinal Fern Tectaria coadunata (J. Smith) C. Christensen from Central Nepal

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Department of Botany, Tribhuvan University, Kirtipur 44618, Nepal
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DAFNAE, Department of Agronomy, Food, Natural Resources, Animals and Environment, Agripolis Campus, University of Padova, 35020 Legnaro (PD), Italy
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Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
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Department of Biology, Science Faculty, Selcuk University, Campus, Konya 42130, Turkey
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Department of Health Sciences, Faculty of Science, University of Mauritius, 230 Réduit, Mauritius
*
Author to whom correspondence should be addressed.
Academic Editors: Gabriela Rapeanu and Nicoleta Stănciuc
Molecules 2019, 24(24), 4457; https://doi.org/10.3390/molecules24244457
Received: 11 November 2019 / Revised: 23 November 2019 / Accepted: 2 December 2019 / Published: 5 December 2019
(This article belongs to the Special Issue Bioactive Compounds from Vegetable Sources)
Tectaria coadunata, an ethnomedicinal fern used in Nepal to treat a large number of diseases, has been poorly studied with regard to its phytochemical composition and possible bioactivity. This study was performed with the aim of supporting traditional medicine as a new source of bioactive constituents. Phytochemical compositions of methanol extracts were determined by nuclear magnetic resonance (NMR), liquid chromatography–diode array detector–mass spectrophotometry (LC-DAD-MS), and liquid chromatography–fluorescence–mass spectrometry. Quali-quantitative data revealed large amount of procyanidins, mainly of the A-type, as well as eriodictyol-7-O-glucuronide and luteolin-7-O-glucoronide as main constituents. The antioxidant, cytotoxic, and inhibitory activity of five enzymes that are implicated in human diseases was evaluated for the extract and fractions. High free-radical scavenging activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays and inhibitory activities against cholinesterases and tyrosinase were observed. Furthermore, a moderate cytotoxic effect was observed on the 2008 and BxPC3 cell lines. Overall results showed potential usefulness of this fern as a source of phytochemicals for pharmaceutical uses. View Full-Text
Keywords: Tectaria coadunata; antioxidant; medicinal fern; chromatography; procyanidins; flavonols Tectaria coadunata; antioxidant; medicinal fern; chromatography; procyanidins; flavonols
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Shrestha, S.S.; Sut, S.; Barbon Di Marco, S.; Zengin, G.; Gandin, V.; De Franco, M.; Pant, D.R.; Mahomoodally, M.F.; Dall’Acqua, S.; Rajbhandary, S. Phytochemical Fingerprinting and In Vitro Bioassays of the Ethnomedicinal Fern Tectaria coadunata (J. Smith) C. Christensen from Central Nepal. Molecules 2019, 24, 4457.

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