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Open AccessArticle

Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins

1
School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China
2
Department of Chinese Materia Medica, Shanxi University of Chinese Medicine, Jinzhong 030619, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2019, 24(23), 4379; https://doi.org/10.3390/molecules24234379
Received: 11 November 2019 / Revised: 21 November 2019 / Accepted: 27 November 2019 / Published: 30 November 2019
Two new octanorlanostane-type triterpenes, euphraticanoids A and B (1 and 2), two new trinorsesquiterpenoids, euphraticanoids C and D (3 and 4), and eight known triterpenoids (5, 6, 813) along with one steroid (7) were isolated from Populus euphratica resins. The structures of these new compounds, including their absolute configurations, were characterized by spectrocsopic, chemical, and computational methods. Biological evaluation revealed that compounds 4, 79, 12, and 13 display neuroprotective activities in H2O2-induced HT-22 cells with 4, 8, and 9 occurring in a concentration-dependent manner and 7, 12, and 13 reaching the maximum effects at 20 μM. Meanwhile, the neuroprotective properties of all isolates were accessed using glutamate-induced SH-SY5Y cells and disclosed that compounds 3, 4, 8, and 9 could dose-dependently protect neural cell injury in a concentration range of 10–40 μM. Finally, a brief structure–activity relationship was briefly discussed. View Full-Text
Keywords: Populus euphratica; plant resins; sesquiterpenoids; triterpenoids; neuroprotection Populus euphratica; plant resins; sesquiterpenoids; triterpenoids; neuroprotection
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MDPI and ACS Style

Liu, Y.-Y.; Huang, D.-L.; Dong, Y.; Qin, D.-P.; Yan, Y.-M.; Cheng, Y.-X. Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins. Molecules 2019, 24, 4379.

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