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Open AccessArticle

Chemical Discrimination of Astragalus mongholicus and Astragalus membranaceus Based on Metabolomics Using UHPLC-ESI-Q-TOF-MS/MS Approach

The Research Institute of Medicine and Pharmacy, Qiqihar Medical University, Bukui Street 333, Qiqihar 161006, China
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Academic Editors: Carlo Siciliano and Anna Napoli
Molecules 2019, 24(22), 4064; https://doi.org/10.3390/molecules24224064
Received: 12 October 2019 / Revised: 30 October 2019 / Accepted: 6 November 2019 / Published: 9 November 2019
Astragalus mongholicus (MG) and Astragalus membranaceus (MJ), both generally known as Huangqi in China, are two perennial herbals widely used in variety diseases. However, there were still some differences in the chemical ingredients between MG and MJ. In this paper, metabolomics combined with the ultra-high performance liquid chromatography coupled with electrospray ionization/quadrupole time-of-flight mass spectrometry (UHPLC-ESI-Q-TOF-MS/MS) was employed to contrastively analyze the chemical constituents between MG and MJ. As a result, principal component analysis showed that MG and MJ were separated clearly. A total of 53 chemical markers were successfully identified for the discrimination of MG and MJ. Of them, the contents of 36 components including Astragaloside I~III, Astragaloside IV, Agroastragaloside I, etc. in MJ were significantly higher than those in MG. On the contrary, the contents of 17 other components including coumaric acid, formononetin, sophoricoside, etc. in MG were obviously higher than those in MJ. The results showed that the distinctive constituents in MG and MJ were remarkable, and MJ may own stronger pharmacological activities than MG. In a word, MG and MJ may be treated as two different herbs. This paper demonstrated that metabolomics was a vitally credible technology to rapidly screen the characteristic chemical composition of traditional Chinese medicine. View Full-Text
Keywords: metabolomics; Astragalus mongholicus; Astragalus membranaceus; ultra-high performance liquid chromatography coupled with electrospray ionization/quadrupoletime-of-flight mass spectrometry; constituents; discrimination metabolomics; Astragalus mongholicus; Astragalus membranaceus; ultra-high performance liquid chromatography coupled with electrospray ionization/quadrupoletime-of-flight mass spectrometry; constituents; discrimination
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Wang, Y.; Liu, L.; Ma, Y.; Guo, L.; Sun, Y.; Liu, Q.; Liu, J. Chemical Discrimination of Astragalus mongholicus and Astragalus membranaceus Based on Metabolomics Using UHPLC-ESI-Q-TOF-MS/MS Approach. Molecules 2019, 24, 4064.

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