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Open AccessArticle

Encapsulation of Upconversion Nanoparticles in Periodic Mesoporous Organosilicas

Institut Charles Gerhardt Montpellier, case 1701, UMR5253, CNRS-UM-ENSCM, Place Eugène Bataillon, 34095 Montpellier, CEDEX 05, France
Institut des Biomolécules Max Mousseron UMR 5247 CNRS, UM-Faculté de Pharmacie, 15 Avenue Charles Flahault, 34093 Montpellier, CEDEX 05, France
Instituto de Ciencia de Materiales de Sevilla (CSIC-US), c/Américo Vespucio, 49, 41092 Seville, Spain
Université Clermont Auvergne, CNRS, SIGMA Clermont, ICCF, F-63000 Clermont–Ferrand, France
Author to whom correspondence should be addressed.
Molecules 2019, 24(22), 4054;
Received: 30 September 2019 / Revised: 30 October 2019 / Accepted: 31 October 2019 / Published: 9 November 2019
(This article belongs to the Special Issue Sol-Gel Chemistry. From Molecule to Functional Materials)
(1) Background: Nanomedicine has recently emerged as a promising field, particularly for cancer theranostics. In this context, nanoparticles designed for imaging and therapeutic applications are of interest. We, therefore, studied the encapsulation of upconverting nanoparticles in mesoporous organosilica nanoparticles. Indeed, mesoporous organosilica nanoparticles have been shown to be very efficient for drug delivery, and upconverting nanoparticles are interesting for near-infrared and X-ray computed tomography imaging, depending on the matrix used. (2) Methods: Two different upconverting-based nanoparticles were synthesized with Yb3+-Er3+ as the upconverting system and NaYF4 or BaLuF5 as the matrix. The encapsulation of these nanoparticles was studied through the sol-gel procedure with bis(triethoxysilyl)ethylene and bis(triethoxysilyl)ethane in the presence of CTAB. (3) Results: with bis(triethoxysilyl)ethylene, BaLuF5: Yb3+-Er3+, nanoparticles were not encapsulated, but anchored on the surface of the obtained mesoporous nanorods BaLuF5: Yb3+-Er3+@Ethylene. With bis(triethoxysilyl)ethane, BaLuF5: Yb3+-Er3+ and NaYF4: Yb3+-Er3+nanoparticles were encapsulated in the mesoporous cubic structure leading to BaLuF5: Yb3+-Er3+@Ethane and NaYF4: Yb3+-Er3+@Ethane, respectively. (4) Conclusions: upconversion nanoparticles were located on the surface of mesoporous nanorods obtained by hydrolysis polycondensation of bis(triethoxysilyl)ethylene, whereas encapsulation occurred with bis(triethoxysilyl)ethane. The later nanoparticles NaYF4: Yb3+-Er3+@Ethane or BaLuF5: Yb3+-Er3+@Ethane were promising for applications with cancer cell imaging or X-ray-computed tomography respectively. View Full-Text
Keywords: upconversion; periodic mesoporous organosilica nanoparticles; cancer upconversion; periodic mesoporous organosilica nanoparticles; cancer
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Rahmani, S.; Mauriello Jimenez, C.; Aggad, D.; González-Mancebo, D.; Ocaña, M.; M. A. Ali, L.; Nguyen, C.; Becerro Nieto, A.I.; Francolon, N.; Oliveiro, E.; Boyer, D.; Mahiou, R.; Raehm, L.; Gary-Bobo, M.; Durand, J.-O.; Charnay, C. Encapsulation of Upconversion Nanoparticles in Periodic Mesoporous Organosilicas. Molecules 2019, 24, 4054.

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