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Open AccessArticle

New Hydroxydecanoic Acid Derivatives Produced by an Endophytic Yeast Aureobasidium pullulans AJF1 from Flowers of Aconitum carmichaeli

1
College of Pharmacy, Duksung Women’s University, Seoul 01369, Korea
2
College of Pharmacy, Yeungnam University, Gyeongsan 38541, Korea
3
College of Korean Medicine, Gachon University, Seongnam 13120, Korea
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(22), 4051; https://doi.org/10.3390/molecules24224051
Received: 13 October 2019 / Revised: 7 November 2019 / Accepted: 7 November 2019 / Published: 8 November 2019
(This article belongs to the Section Bioorganic Chemistry)
Endophytes have been recognized as a source for structurally novel and biologically active secondary metabolites. Among the host plants for endophytes, some medicinal plants that produce pharmaceuticals have been reported to carry endophytes, which could also produce bioactive secondary metabolites. In this study, the medicinal plant Aconitum carmichaeli was selected as a potential source for endophytes. An endophytic microorganism, Aureobasidium pullulans AJF1, harbored in the flower of Aconitum carmichaeli, was cultured on a large scale and extracted with an organic solvent. Extensive chemical investigation of the extracts resulted in isolation of three lipid type compounds (13), which were identified to be (3R,5R)-3,5-dihydroxydecanoic acid (1), (3R,5R)-3-(((3R,5R)-3,5-dihydroxydecanoyl)oxy)-5-hydroxydecanoic acid (2), and (3R,5R)-3-(((3R,5R)-5-(((3R,5R)-3,5-dihydroxydecanoyl)oxy)-3-hydroxydecanoyl)oxy)-5-hydroxydecanoic acid (3) by chemical methods in combination with spectral analysis. Compounds 2 and 3 had new structures. Absolute configurations of the isolated compounds (13) were established using modified Mosher’s method together with analysis of NMR data for their acetonide derivatives. All the isolates (13) were evaluated for antibiotic activities against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and their cytotoxicities against MCF-7 cancer cells. Unfortunately, they showed low antibiotic activities and cytotoxic activities. View Full-Text
Keywords: endophyte; Aureobasidium pullulans; hydroxydecanoic acid; Aconitum carmichaeli endophyte; Aureobasidium pullulans; hydroxydecanoic acid; Aconitum carmichaeli
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Choi, H.G.; Kim, J.W.; Choi, H.; Kang, K.S.; Shim, S.H. New Hydroxydecanoic Acid Derivatives Produced by an Endophytic Yeast Aureobasidium pullulans AJF1 from Flowers of Aconitum carmichaeli. Molecules 2019, 24, 4051.

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