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Open AccessArticle

Study on Hypoglycemic Effect of the Drug Pair of Astragalus Radix and Dioscoreae Rhizoma in T2DM Rats by Network Pharmacology and Metabonomics

by Qian Guo 1,2,†, Wanlin Niu 1,3,†, Xuejia Li 1,3, Hongru Guo 4, Na Zhang 3, Xiufeng Wang 5,* and Lirong Wu 1,2,*
1
Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China
2
School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China
3
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China
4
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China
5
College of Medical Information Engineering, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China
*
Authors to whom correspondence should be addressed.
Theses authors contribute equally to this work.
Molecules 2019, 24(22), 4050; https://doi.org/10.3390/molecules24224050
Received: 22 September 2019 / Revised: 2 November 2019 / Accepted: 6 November 2019 / Published: 8 November 2019
(This article belongs to the Section Natural Products Chemistry)
Type 2 diabetes mellitus (T2DM) is a metabolic disease accompanied by a series of diseases such as diabetic nephropathy. The drug pair (HS) of Astragalus Radix (HQ) and Dioscoreae Rhizoma (SY) was designed by Dr. Shi Jinmo to improve the treatment of T2DM. However, the exact mechanism involved requires further clarification. In this work, 1H-NMR–based metabonomics and network pharmacology were adopted. Metabolic profiling indicated that the metabolic perturbation was reduced after HS treatment. The results found 21 biomarkers. According to the network pharmacology, we found that the regulation of T2DM was primarily associated with 18 active compounds in HS. These active compounds mainly had an effect on 135 targets. Subsequently, combining network pharmacology and metabonomics, we found four target proteins, which indicated that HS has potential hypoglycemic effects through regulating monoamine oxidases B (MAOB), acetyl-CoA carboxylase 1 (ACACA), carbonic anhydrase 2 (CA2), and catalase (CAT). In conclusion, the result showed that these four targets might be the most relevant targets for the treatment of T2DM with HS. This study clarified the mechanism of HS in the treatment of T2DM and also confirmed the feasibility of combining metabonomics and network pharmacology to study the mechanisms of traditional Chinese medicine (TCM). In the future, this approach may be a potentially powerful tool to discovery active components of traditional Chinese medicines and elucidate their mechanisms. View Full-Text
Keywords: Dioscoreae Rhizomacomes; Astragalus Radix; type 2 diabetes; metabolomics; network pharmacology Dioscoreae Rhizomacomes; Astragalus Radix; type 2 diabetes; metabolomics; network pharmacology
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Guo, Q.; Niu, W.; Li, X.; Guo, H.; Zhang, N.; Wang, X.; Wu, L. Study on Hypoglycemic Effect of the Drug Pair of Astragalus Radix and Dioscoreae Rhizoma in T2DM Rats by Network Pharmacology and Metabonomics. Molecules 2019, 24, 4050.

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