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Open AccessFeature PaperArticle

One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool

Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269-3060, USA
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Academic Editor: John Spencer
Molecules 2019, 24(20), 3639; https://doi.org/10.3390/molecules24203639
Received: 19 September 2019 / Revised: 4 October 2019 / Accepted: 8 October 2019 / Published: 9 October 2019
(This article belongs to the Special Issue Microwave-Mediated Chemistry)
A methodology is reported for the preparation of 2-aryl-benzimidazole-3-oxide derivatives. By means of a one-pot two-step protocol, a library of 42 new compounds has been prepared. Reactions were performed in a total time of 40 min using microwave heating as a tool. A streamlined work-up process was also developed, allowing for facile isolation of the products. The methodology offers a more sustainable approach than previous routes, with only water and ethanol being used as solvents, and the products being isolated by means of a simple filtration without the need for any further purification. View Full-Text
Keywords: microwave heating; benzimidazole; benzimidazole N-oxide; green chemistry microwave heating; benzimidazole; benzimidazole N-oxide; green chemistry
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MDPI and ACS Style

Politano, F.; Gran-Magano, A.K.; Leadbeater, N.E. One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool. Molecules 2019, 24, 3639.

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