Next Article in Journal
Nematicidal Activities of Three Naphthoquinones against the Pine Wood Nematode, Bursaphelenchus xylophilus
Previous Article in Journal
Removal of Ammonia from the Municipal Waste Treatment Effluents using Natural Minerals
Open AccessArticle

Voriconazole-Based Salts Are Active against Multidrug-Resistant Human Pathogenic Yeasts

1
Department of Organic Chemistry, Gdańsk University of Technology, 11/12 G. Narutowicza Str., 80-233 Gdańsk, Poland
2
Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, 11/12 G. Narutowicza Str., 80-233 Gdańsk, Poland
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(20), 3635; https://doi.org/10.3390/molecules24203635
Received: 20 August 2019 / Revised: 3 October 2019 / Accepted: 6 October 2019 / Published: 9 October 2019
(This article belongs to the Section Medicinal Chemistry)
Voriconazole (VOR) hydrochloride is unequivocally converted into VOR lactates and valinates upon reaction with silver salts of organic acids. This study found that the anticandidal in vitro activity of these compounds was comparable or slightly better than that of VOR. The Candida albicans clinical isolate overexpressing CaCDR1/CaCDR2 genes, highly resistant to VOR, was apparently more susceptible to VOR salts. On the other hand, the susceptibility of another C. albicans clinical isolate (demonstrating multidrug resistance due to the overexpression of CaMDR1) to VOR salts was comparable to that to VOR. Comparative studies on the influence of VOR and its salts on Rhodamine 6G efflux from susceptible and multidrug-resistant C. albicans cells revealed that VOR salts are poorer substrates for the CaCdr1p drug efflux pump than VOR. View Full-Text
Keywords: voriconazole; Candida albicans; multidrug resistance voriconazole; Candida albicans; multidrug resistance
Show Figures

Graphical abstract

MDPI and ACS Style

Szepiński, E.; Martynow, D.; Szweda, P.; Milewska, M.J.; Milewski, S. Voriconazole-Based Salts Are Active against Multidrug-Resistant Human Pathogenic Yeasts. Molecules 2019, 24, 3635.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop