Next Article in Journal
Cajanolactone A from Cajanus cajan Promoted Osteoblast Differentiation in Human Bone Marrow Mesenchymal Stem Cells via Stimulating Wnt/LRP5/β-Catenin Signaling
Previous Article in Journal
Laminaria digitata and Palmaria palmata Seaweeds as Natural Source of Catalysts for the Cycloaddition of CO2 to Epoxides
Previous Article in Special Issue
PPARα Agonist Suppresses Inflammation after Corneal Alkali Burn by Suppressing Proinflammatory Cytokines, MCP-1, and Nuclear Translocation of NF-κB
Article Menu

Export Article

Open AccessArticle
Molecules 2019, 24(2), 270; https://doi.org/10.3390/molecules24020270

Clofibrate Treatment Decreases Inflammation and Reverses Myocardial Infarction-Induced Remodelation in a Rodent Experimental Model

1
Department of Pharmacology, National Institute of Cardiology Ignacio Chávez, Juan Badiano No.1, Col. Sección XVI, Tlalpan, Z.C., Mexico City 14080, Mexico
2
Department of Pathology, National Institute of Cardiology Ignacio Chávez, Juan Badiano No.1, Col. Sección XVI, Tlalpan, Z.C., Mexico City 14080, Mexico
3
Department of Haemodynamics, National Institute of Cardiology Ignacio Chávez, Juan Badiano No.1, Col. Sección XVI, Tlalpan, Z.C., Mexico City 14080, Mexico
I.-L.L. and S.-A.M. share the first authorship of this paper.
*
Author to whom correspondence should be addressed.
Academic Editors: Raffaele Capasso and Fabio Arturo Iannotti
Received: 1 December 2018 / Revised: 4 January 2019 / Accepted: 8 January 2019 / Published: 12 January 2019
(This article belongs to the Special Issue Role of PPAR Receptors in Human Health and Disease)
Full-Text   |   PDF [2027 KB, uploaded 12 January 2019]   |  

Abstract

Myocardial infarction (MI) initiates an inflammatory response that promotes both beneficial and deleterious effects. The early response helps the myocardium to remove damaged tissue; however, a prolonged later response brings cardiac remodeling characterized by functional, metabolic, and structural pathological changes. Current pharmacological treatments have failed to reverse ischemic-induced cardiac damage. Therefore, our aim was to study if clofibrate treatment was capable of decreasing inflammation and apoptosis, and reverse ventricular remodeling and MI-induced functional damage. Male Wistar rats were assigned to (1) Sham coronary artery ligation (Sham) or (2) Coronary artery ligation (MI). Seven days post-MI, animals were further divided to receive vehicle (V) or clofibrate (100 mg/kg, C) for 7 days. The expression of IL-6, TNF-α, and inflammatory related molecules ICAM-1, VCAM-1, MMP-2 and -9, nuclear NF-kB, and iNOS, were elevated in MI-V. These inflammatory biomarkers decreased in MI-C. Also, apoptotic proteins (Bax and pBad) were elevated in MI-V, while clofibrate augmented anti-apoptotic proteins (Bcl-2 and 14-3-3ε). Clofibrate also protected MI-induced changes in ultra-structure. The ex vivo evaluation of myocardial functioning showed that left ventricular pressure and mechanical work decreased in infarcted rats; clofibrate treatment raised those parameters to control values. Echocardiogram showed that clofibrate partially reduced LV dilation. In conclusion, clofibrate decreases cardiac remodeling, decreases inflammatory molecules, and partly preserves myocardial diameters. View Full-Text
Keywords: Myocardial infarction; inflammation; ventricular remodeling; reversion of damage; clofibrate; PPARα Myocardial infarction; inflammation; ventricular remodeling; reversion of damage; clofibrate; PPARα
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Ibarra-Lara, L.; Sánchez-Aguilar, M.; Soria-Castro, E.; Vargas-Barrón, J.; Roldán, F.J.; Pavón, N.; Torres-Narváez, J.C.; Cervantes-Pérez, L.G.; Pastelín-Hernández, G.; Sánchez-Mendoza, A. Clofibrate Treatment Decreases Inflammation and Reverses Myocardial Infarction-Induced Remodelation in a Rodent Experimental Model. Molecules 2019, 24, 270.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top