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Molecules 2019, 24(2), 223; https://doi.org/10.3390/molecules24020223

Hop Extract Acts as an Antioxidant with Antimicrobial Effects against Propionibacterium Acnes and Staphylococcus Aureus

1
Research Centre skinitial, Department of Dermatology, University Medical Center, 79104 Freiburg, Germany
2
Institute for Infection Prevention and Hospital Epidemiology, Medical Center, University of Freiburg, 79106 Freiburg, Germany
3
BSI-Beauty Science Intelligence GmbH, 30855 Langenhagen, Germany
4
Flavex Naturextrakte GmbH, 66780 Rehlingen, Germany
Both authors contributed equally to the paper.
*
Author to whom correspondence should be addressed.
Academic Editors: Maria Daglia, Simone Carradori and Annabella Vitalone
Received: 11 December 2018 / Revised: 29 December 2018 / Accepted: 3 January 2019 / Published: 9 January 2019
(This article belongs to the Special Issue Natural Active Agents Against Bacteria, Fungi and Parasites)
Full-Text   |   PDF [1259 KB, uploaded 9 January 2019]   |  

Abstract

Acne is associated with hyperkeratosis, elevated levels of skin sebum and growth of Propionibacterium acnes (P. acnes) and Staphylococcus aureus (S. aureus). Furthermore, P. acnes promotes inflammation by inducing IL-6 production and oxidative stress. The aim of this study was to assess the antioxidant, anti-inflammatory and antibacterial potential of a hop-CO2-extract with 50% humulone and lupulone. The susceptibility of P. acnes and S. aureus to the hop extract was tested by using the broth microdilution technique. The minimal inhibitory concentrations (MIC) for P. acnes and S. aureus were 3.1 and 9.4 µg/mL, respectively. In addition, the hop extract showed an antioxidative effect with a half maximal inhibitory concentration (IC50) of 29.43 µg/mL as well as additional anti-inflammatory effects by reducing the IL-6 expression (IC50: 0.8 µg/mL). In addition, a gel formulation with 0.3% hop extract (w/w) had antibacterial activity against P. acnes and S. aureus (inhibition zone value: 5.5 mm and 3 mm, respectively) which was significantly superior to the placebo gel. The positive control (a gel with the antibiotic clindamycin) showed an inhibition zone of 9 mm. Due to its antioxidant, anti-inflammatory and antibacterial effects hop extract might be a treatment option for acne-prone skin. View Full-Text
Keywords: acne; P. acnes; S. aureus; hop extract; antimicrobial activity; antioxidant activity acne; P. acnes; S. aureus; hop extract; antimicrobial activity; antioxidant activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Weber, N.; Biehler, K.; Schwabe, K.; Haarhaus, B.; Quirin, K.-W.; Frank, U.; Schempp, C.M.; Wölfle, U. Hop Extract Acts as an Antioxidant with Antimicrobial Effects against Propionibacterium Acnes and Staphylococcus Aureus. Molecules 2019, 24, 223.

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