Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu “Kadsura coccinea” Stems
Abstract
:1. Introduction
2. Results and Discussion
3. Experimental
3.1. General
3.2. Plant Material
3.3. Extraction and Isolation
3.3.1. Kadsuricoccin A (1)
3.3.2. Kadsuricoccin B (2)
3.4. Acetylcholinesterase (AchE)-Inhibitory Bioassay
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Sample Availability: Samples of the compounds are not available from the authors. |
Compound | 1 (in CDCl3) | 2 (in CDCl3) | ||
---|---|---|---|---|
No. | δH mult. (J in Hz) | δC | δH mult. (J in Hz) | δC |
1 | 2.01 m 1.87 m | 30.2 t | 1.71 m 2.21 m | 32.1 t |
2 | 2.29 m | 30.3 t | 2.87 ddd, (7.2, 12.0, 14.8) 2.21 m | 33.2 t |
3 | - | 174.8 s | - | 221.6 s |
4 | - | 147.0 s | - | 47.0 s |
5 | 2.18 m | 47.0 d | 2.41 s | 46.3 d |
6 | 1.95 m 1.49 m | 22.1 t | 1.53 dd, (7.6, 12.9) 1.34 m | 19.0 t |
7 | 2.08 m 1.17 m | 27.3 t | 1.97 m 1.29 d, (6.3) | 31.2 t |
8 | - | 37.4 s | - | 37.5 s |
9 | 2.25 m | 41.2 d | 2.40 m | 46.9 d |
10 | 37.7 s | 35.6 s | ||
11 | 2.21 m | 24.7 t | 6.27 dd, (2.9, 10.2) | 121.5 d |
12 | 6.65 dd, (3.4, 3.6) | 131.4 d | 5.59 d, (10.2) | 126.6 d |
13 | - | 144.1 s | - | 140.3 s |
14 | - | 48.6 s | - | 55.1 s |
15 | 1.99 m 1.54 m | 26.8 t | 2.43 m | 27.8 t |
16 | 2.46 m 2.28 m | 36.1 t | 1.38 m | 28.6 t |
17 | - | 207.1 s | - | 138.8 s |
18 | 1.18 s | 23.4 q | 1.02 s | 22.0 q |
19 | 0.91 s | 17.7 q | 0.89 s | 23.9 q |
20 | 4.96 s 4.84 s | 113.4 t | 2.66 m | 31.7 d |
21 | 1.82 s | 26.9 q | 1.01 d, (7.6) | 19.2 q |
22 | 0.94 s | 25.1 q | 1.44 m | 34.9 t |
23/OMe | 3.69 s | 51.7 q | 2.32 dd, (8.8, 16.5) | 28.1 t |
24 | 5.86 t, (7.2) | 139.3 d | ||
25 | 128.7 s | |||
26 | 171.5 s | |||
27 | 1.87 s | 19.7 q | ||
28 | 1.11 s | 28.2 q | ||
29 | 1.03 s | 18.3 q | ||
30 | 0.95 s | 19.0 q |
Compounds | AII (%) |
---|---|
1 | 68.96 ± 0.19 |
2 | 57.8 ± 0.11 |
3 | 37.75 ± 0.12 |
4 | 17.23 ± 0.08 |
5 | 25.66 ± 0.18 |
Blank control | 8.94 ± 0.09 |
Tacrine (positive control, 9.4 nM) | 79.80 ± 0.20 |
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Huang, S.Z.; Duan, L.P.; Wang, H.; Mei, W.L.; Dai, H.F. Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu “Kadsura coccinea” Stems. Molecules 2019, 24, 3628. https://doi.org/10.3390/molecules24193628
Huang SZ, Duan LP, Wang H, Mei WL, Dai HF. Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu “Kadsura coccinea” Stems. Molecules. 2019; 24(19):3628. https://doi.org/10.3390/molecules24193628
Chicago/Turabian StyleHuang, Sheng Zhuo, Lin Ping Duan, Hao Wang, Wen Li Mei, and Hao Fu Dai. 2019. "Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu “Kadsura coccinea” Stems" Molecules 24, no. 19: 3628. https://doi.org/10.3390/molecules24193628