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Open AccessArticle

Fabrication of pH-Sensitive Tetramycin Releasing Gel and Its Antibacterial Bioactivity against Ralstonia solanacearum

by Xiaozhou Ma 1,2,†, Shunyu Xiang 2,3,†, Huijun Xie 3, Linhai He 1, Xianchao Sun 2,3, Yongqiang Zhang 2,3,* and Jin Huang 1,2,*
1
School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China
2
Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, Southwest University, Chongqing 400715 China
3
College of Plant Protection, State Cultivation Base of Crop Stress Biology for Southern Mountainous Land, Southwest University, Chongqing 400715 China
*
Authors to whom correspondence should be addressed.
The authors contributed equally to this work.
Molecules 2019, 24(19), 3606; https://doi.org/10.3390/molecules24193606
Received: 25 August 2019 / Revised: 30 September 2019 / Accepted: 2 October 2019 / Published: 7 October 2019
(This article belongs to the Section Materials Chemistry)
Ralstonia solanacearum (R. solanacearum)-induced bacterial wilt of the nightshade family causes a great loss in agricultural production annually. Although there has been some efficient pesticides against R. solanacearum, inaccurate pesticide releasing according to the onset time of bacterial wilt during the use of pesticides still hinders the disease management efficiency. Herein, on the basis of the soil pH change during R. solanacearum growth, and pH sensitivity of the Schiff base structure, a pH-sensitive oxidized alginate-based double-crosslinked gel was fabricated as a pesticide carrier. The gel was prepared by crosslinking oxidized sodium alginate (OSA) via adipic dihydrazide (ADH) and Ca2+. After loading tetramycin into the gel, it showed a pH-dependent pesticide releasing behavior and anti-bacterial activity against R. solanacearum. Further study also showed that the inhibition rate of the tetramycin-loaded gel was higher than that of industrial pesticide difenoconazole. This work aimed to reduce the difficulty of pesticide administration in the high incidence period of bacterial wilt and we believe it has a great application potential in nightshade production. View Full-Text
Keywords: pH-dependent pesticide releasing; double-crosslinking gel; alginate gel; tetramycin releasing; Ralstonia solanacearum pH-dependent pesticide releasing; double-crosslinking gel; alginate gel; tetramycin releasing; Ralstonia solanacearum
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Ma, X.; Xiang, S.; Xie, H.; He, L.; Sun, X.; Zhang, Y.; Huang, J. Fabrication of pH-Sensitive Tetramycin Releasing Gel and Its Antibacterial Bioactivity against Ralstonia solanacearum. Molecules 2019, 24, 3606.

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