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Article

Identification and Semi-Synthesis of 3-O-Protocatechuoylceanothic Acid, a Novel and Natural GPR120 Agonist

1
College of Pharmacy, CHA University, 120 Haeryong-ro, Pocheon 11160, Gyeonggi-do, Korea
2
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
3
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Sookmyung Women’s University, Seoul 04310, Korea
*
Author to whom correspondence should be addressed.
In memory of late professor Sang Hyun Sung.
Molecules 2019, 24(19), 3487; https://doi.org/10.3390/molecules24193487
Received: 10 September 2019 / Revised: 24 September 2019 / Accepted: 25 September 2019 / Published: 26 September 2019
(This article belongs to the Section Medicinal Chemistry)
The identification and three step synthesis of 3-O-protocatechuoylceanothic acid, a novel and natural GPR120 agonist, is described. This ceanothane-type triterpenoid was identified from the components of Ziziphus jujuba roots and was found to be a new GPR120 agonist with a novel structure. We synthetically converted ceanothic acid, which does not have GPR120 agonist activity, into 3-O-protocatechuoylceanothic acid in three steps. In addition, we present the corrected NMR spectrum of 3-O-protocatechuoylceanothic acid based on our synthesis. View Full-Text
Keywords: G protein-coupled receptor; GPR120; agonist; 3-O-protocatechuoylceanothic acid; semi-synthesis G protein-coupled receptor; GPR120; agonist; 3-O-protocatechuoylceanothic acid; semi-synthesis
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MDPI and ACS Style

Lim, C.; Park, J.G.; Kang, K.B.; Suh, Y.-G. Identification and Semi-Synthesis of 3-O-Protocatechuoylceanothic Acid, a Novel and Natural GPR120 Agonist . Molecules 2019, 24, 3487. https://doi.org/10.3390/molecules24193487

AMA Style

Lim C, Park JG, Kang KB, Suh Y-G. Identification and Semi-Synthesis of 3-O-Protocatechuoylceanothic Acid, a Novel and Natural GPR120 Agonist . Molecules. 2019; 24(19):3487. https://doi.org/10.3390/molecules24193487

Chicago/Turabian Style

Lim, Changjin, Jung Gyu Park, Kyo Bin Kang, and Young-Ger Suh. 2019. "Identification and Semi-Synthesis of 3-O-Protocatechuoylceanothic Acid, a Novel and Natural GPR120 Agonist " Molecules 24, no. 19: 3487. https://doi.org/10.3390/molecules24193487

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