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Open AccessArticle

Efficient Extraction of Anti-Inflammatory Active Ingredients from Schefflera octophylla Leaves Using Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with HPLC

1,2,3, 2,4, 1,3, 2,4, 1,3,* and 2,4,*
1
Engineering Research center of Molecular Medicine, Ministry of Education, Xiamen 361021, China
2
National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China
3
School of Biomedical Sciences and School of Medicine, Huaqiao University, Xiamen 361021, China
4
Joint International Research Laboratory of Food & Medicine Resource Function, Kaifeng 475004, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Johan Jacquemin and Fouad Ghamouss
Molecules 2019, 24(16), 2942; https://doi.org/10.3390/molecules24162942
Received: 14 July 2019 / Revised: 6 August 2019 / Accepted: 12 August 2019 / Published: 14 August 2019
(This article belongs to the Special Issue Ionic Liquids, from Their Synthesis to Their Applications)
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Abstract

Schefflera octophylla (Lour.) Harms, a kind of traditional Chinese medicine (TCM), is commonly used for anti-inflammatory, analgesic, rheumatism, fever, and hemostasis therapy. In our previous studies, two major triterpenoids were isolated and identified from leaves of S. octophylla, and evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 cells; both of them displayed significant anti-inflammatory activities at their noncytotoxic concentrations. Therefore, it is very useful to establish an efficient and green extraction method to isolated the two major triterpenoids from leaves of S. octophylla. In this paper, ionic liquid based ultrasonic-assisted extraction (ILUAE) was successfully applied to extract the two major triterpenoids from leaves of S. octophylla. Four single factors (ionic liquids (ILs) concentration, solid–liquid ratio, centrifugal speed, mesh number), with a greater impact on extraction rate, were selected from a variety of influencing factors, and the optimal conditions were obtained by Box–Behnken response surface methodology (RSM). Under optimal conditions, the total extraction yield and extraction rate of two triterpenoids were 288.03 mg/g and 28.80%, respectively, which was 6.80% higher than that of 70% Ethanol (220 mg/g and 22%, respectively). View Full-Text
Keywords: Schefflera octophylla (Lour.) Harms; ionic liquid; response surface method Schefflera octophylla (Lour.) Harms; ionic liquid; response surface method
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Liu, X.; Niu, Y.; Liu, J.; Shi, M.; Xu, R.; Kang, W. Efficient Extraction of Anti-Inflammatory Active Ingredients from Schefflera octophylla Leaves Using Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with HPLC. Molecules 2019, 24, 2942.

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