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Article

Five New Cucurbitane-Type Triterpenoid Glycosides from the Rhizomes of Hemsleya penxianensis with Cytotoxic Activities

by
De-Li Chen
1,†,
Xu-Dong Xu
2,†,
Rong-Tao Li
1,
Bo-Wen Wang
3,
Meng Yu
1,2,
Yang-Yang Liu
1,* and
Guo-Xu Ma
1,2,*
1
Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medical College (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Haikou 570311, China
2
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing 100193, China
3
School of Chemical Engineering and Technology, Hainan University, Haikou 570228, China
*
Authors to whom correspondence should be addressed.
†
These two authors contributed equally to this work.
Molecules 2019, 24(16), 2937; https://doi.org/10.3390/molecules24162937
Submission received: 1 August 2019 / Revised: 11 August 2019 / Accepted: 13 August 2019 / Published: 13 August 2019
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Abstract

Five new cucurbitane-typetriterpenoid glycosides, named Xuedanoside F–J (1–5), were obtained from the rhizomes of Hemsleya penxianensis (Xue dan), which belongs to the family of Cucurbitaceae. These new compounds were elucidated byspectroscopic analysis, including 1D, 2D NMR, and HR-ESI-MS spectra. Additionally, all the isolates were evaluated for cytotoxicity against three human cancer cell lines (Hela, MCF-7, and A-549) with the IC50 ranging from 2.25 to 49.44 µM in vitro with treatment 48 h and showed low cytotoxicity in human normal liver L-02 cells (IC50 > 50 µM). Compound 5 showed the most significant cytotoxic activity with the IC50 value of 2.25, 4.72, and 5.33 µM in 48 h, respectively.
Keywords: Hemsleya penxianensis; cucurbitane-typetriterpenoid glycosides; cytotoxicity Hemsleya penxianensis; cucurbitane-typetriterpenoid glycosides; cytotoxicity
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MDPI and ACS Style

Chen, D.-L.; Xu, X.-D.; Li, R.-T.; Wang, B.-W.; Yu, M.; Liu, Y.-Y.; Ma, G.-X. Five New Cucurbitane-Type Triterpenoid Glycosides from the Rhizomes of Hemsleya penxianensis with Cytotoxic Activities. Molecules 2019, 24, 2937. https://doi.org/10.3390/molecules24162937

AMA Style

Chen D-L, Xu X-D, Li R-T, Wang B-W, Yu M, Liu Y-Y, Ma G-X. Five New Cucurbitane-Type Triterpenoid Glycosides from the Rhizomes of Hemsleya penxianensis with Cytotoxic Activities. Molecules. 2019; 24(16):2937. https://doi.org/10.3390/molecules24162937

Chicago/Turabian Style

Chen, De-Li, Xu-Dong Xu, Rong-Tao Li, Bo-Wen Wang, Meng Yu, Yang-Yang Liu, and Guo-Xu Ma. 2019. "Five New Cucurbitane-Type Triterpenoid Glycosides from the Rhizomes of Hemsleya penxianensis with Cytotoxic Activities" Molecules 24, no. 16: 2937. https://doi.org/10.3390/molecules24162937

APA Style

Chen, D.-L., Xu, X.-D., Li, R.-T., Wang, B.-W., Yu, M., Liu, Y.-Y., & Ma, G.-X. (2019). Five New Cucurbitane-Type Triterpenoid Glycosides from the Rhizomes of Hemsleya penxianensis with Cytotoxic Activities. Molecules, 24(16), 2937. https://doi.org/10.3390/molecules24162937

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