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Article

Synergistic Effects of Anionic/Cationic Dendrimers and Levofloxacin on Antibacterial Activities

by
Natalia Wrońska
1,
Jean Pierre Majoral
2,
Dietmar Appelhans
3,
Maria Bryszewska
4 and
Katarzyna Lisowska
1,*
1
Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-236 Lodz, Poland
2
CNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse CEDEX 4, France
3
Leibniz Institute of Polymer Research Dresden, Hohe Straße 6, D-01069 Dresden, Germany
4
Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska Street, 90-236 Lodz, Poland
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(16), 2894; https://doi.org/10.3390/molecules24162894
Submission received: 23 July 2019 / Revised: 2 August 2019 / Accepted: 6 August 2019 / Published: 9 August 2019
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Abstract

Despite the numerous studies on dendrimers for biomedical applications, the antibacterial activity of anionic phosphorus dendrimers has not been explored. In our research, we evaluated the antibacterial activity of modified polycationic and polyanionic dendrimers in combination with levofloxacin (LVFX) against Gram-negative (Escherichia coli ATCC 25922, Proteus hauseri ATCC 15442) and Gram-positive (Staphylococcus aureus ATCC 6538) bacteria. In the case of Gram-negative bacteria, we concluded that a combination of dendrimers and antibiotic gave satisfactory results due to a synergistic effect. The use of fluoroquinolone antibiotics, such as LVFX, not only caused resistance in disease-causing microorganisms but also increased environmental pollution. Therefore, reduction of drug dosage is of general interest.
Keywords: dendrimers; antibacterial activity; levofloxacin; synergistic effects dendrimers; antibacterial activity; levofloxacin; synergistic effects

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MDPI and ACS Style

Wrońska, N.; Majoral, J.P.; Appelhans, D.; Bryszewska, M.; Lisowska, K. Synergistic Effects of Anionic/Cationic Dendrimers and Levofloxacin on Antibacterial Activities. Molecules 2019, 24, 2894. https://doi.org/10.3390/molecules24162894

AMA Style

Wrońska N, Majoral JP, Appelhans D, Bryszewska M, Lisowska K. Synergistic Effects of Anionic/Cationic Dendrimers and Levofloxacin on Antibacterial Activities. Molecules. 2019; 24(16):2894. https://doi.org/10.3390/molecules24162894

Chicago/Turabian Style

Wrońska, Natalia, Jean Pierre Majoral, Dietmar Appelhans, Maria Bryszewska, and Katarzyna Lisowska. 2019. "Synergistic Effects of Anionic/Cationic Dendrimers and Levofloxacin on Antibacterial Activities" Molecules 24, no. 16: 2894. https://doi.org/10.3390/molecules24162894

APA Style

Wrońska, N., Majoral, J. P., Appelhans, D., Bryszewska, M., & Lisowska, K. (2019). Synergistic Effects of Anionic/Cationic Dendrimers and Levofloxacin on Antibacterial Activities. Molecules, 24(16), 2894. https://doi.org/10.3390/molecules24162894

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