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Open AccessReview

Gingers and Their Purified Components as Cancer Chemopreventative Agents

by 1,*,† and 2
Retired from Department of Medicine, Division of Medical Oncology, Ohio State University, Columbus 43210, OH, USA
Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA
Author to whom correspondence should be addressed.
Current address: 3849 Jester Ct. NW, Olympia, WA 98502, USA.
Academic Editor: Lars P. Christensen
Molecules 2019, 24(16), 2859;
Received: 17 July 2019 / Revised: 29 July 2019 / Accepted: 5 August 2019 / Published: 7 August 2019
(This article belongs to the Special Issue Natural Products for Cancer Chemoprevention)
Chemoprevention by ingested substituents is the process through which nutraceuticals and/or their bioactive components antagonize carcinogenesis. Carcinogenesis is the course of action whereby a normal cell is transformed into a neoplastic cell. This latter action involves several steps, starting with initiation and followed by promotion and progression. Driving these stages is continued oxidative stress and inflammation, which in turn, causes a myriad of aberrant gene expressions and mutations within the transforming cell population and abnormal gene expressions by the cells within the surrounding lesion. Chemoprevention of cancer with bioreactive foods or their extracted/purified components occurs primarily via normalizing these inappropriate gene activities. Various foods/agents have been shown to affect different gene expressions. In this review, we discuss how the chemoprevention activities of gingers antagonize cancer development. View Full-Text
Keywords: gingerols; shogaols; paradols; zingerone; zerumbone; cancer chemoprevention; apoptosis gingerols; shogaols; paradols; zingerone; zerumbone; cancer chemoprevention; apoptosis
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MDPI and ACS Style

Lechner, J.F.; Stoner, G.D. Gingers and Their Purified Components as Cancer Chemopreventative Agents. Molecules 2019, 24, 2859.

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