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Review

Terpene Derivatives as a Potential Agent against Antimicrobial Resistance (AMR) Pathogens

1
Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
2
Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
3
Department of Aquaculture, Faculty of Agriculture, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
4
School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia
5
Health Sciences Division, Abu Dhabi Women’s College, Higher Colleges of Technology, 41012 Abu Dhabi, UAE
*
Author to whom correspondence should be addressed.
Academic Editor: Pinarosa Avato
Molecules 2019, 24(14), 2631; https://doi.org/10.3390/molecules24142631
Received: 24 April 2019 / Revised: 29 May 2019 / Accepted: 3 June 2019 / Published: 19 July 2019
(This article belongs to the Special Issue Natural Products and Drug Discovery)
The evolution of antimicrobial resistance (AMR) in pathogens has prompted extensive research to find alternative therapeutics. Plants rich with natural secondary metabolites are one of the go-to reservoirs for discovery of potential resources to alleviate this problem. Terpenes and their derivatives comprising of hydrocarbons, are usually found in essential oils (EOs). They have been reported to have potent antimicrobial activity, exhibiting bacteriostatic and bactericidal effects against tested pathogens. This brief review discusses the activity of terpenes and derivatives against pathogenic bacteria, describing the potential of the activity against AMR followed by the possible mechanism exerted by each terpene class. Finally, ongoing research and possible improvisation to the usage of terpenes and terpenoids in therapeutic practice against AMR are discussed. View Full-Text
Keywords: terpenes; terpenoids; antimicrobial resistance; synergy terpenes; terpenoids; antimicrobial resistance; synergy
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MDPI and ACS Style

Mahizan, N.A.; Yang, S.-K.; Moo, C.-L.; Song, A.A.-L.; Chong, C.-M.; Chong, C.-W.; Abushelaibi, A.; Lim, S.-H.E.; Lai, K.-S. Terpene Derivatives as a Potential Agent against Antimicrobial Resistance (AMR) Pathogens. Molecules 2019, 24, 2631. https://doi.org/10.3390/molecules24142631

AMA Style

Mahizan NA, Yang S-K, Moo C-L, Song AA-L, Chong C-M, Chong C-W, Abushelaibi A, Lim S-HE, Lai K-S. Terpene Derivatives as a Potential Agent against Antimicrobial Resistance (AMR) Pathogens. Molecules. 2019; 24(14):2631. https://doi.org/10.3390/molecules24142631

Chicago/Turabian Style

Mahizan, Nik A., Shun-Kai Yang, Chew-Li Moo, Adelene A.-L. Song, Chou-Min Chong, Chun-Wie Chong, Aisha Abushelaibi, Swee-Hua E. Lim, and Kok-Song Lai. 2019. "Terpene Derivatives as a Potential Agent against Antimicrobial Resistance (AMR) Pathogens" Molecules 24, no. 14: 2631. https://doi.org/10.3390/molecules24142631

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