New 11,20-Epoxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae)
Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
Department of Anaesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Authors to whom correspondence should be addressed.
Academic Editors: Pavel B. Drasar and Vladimir A. Khripach
Received: 14 June 2019 / Revised: 29 June 2019 / Accepted: 5 July 2019 / Published: 7 July 2019
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Two new 11,20-epoxybriaranes, fragilides P (1
) and Q (2
), as well as two known analogues, robustolide F (3
) and juncin Z (4
), were obtained from the gorgonian coral Junceella fragilis
. The structures, including the absolute configurations of briaranes 1
, were elucidated by using spectroscopic methods and comparing the spectroscopic and rotation data with those of known related analogues. Briarane 4
decreased the generation of superoxide anions by human neutrophils. The propionate group in 1
is rarely found.
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Lin, C.-C.; Su, J.-H.; Chen, W.-F.; Wen, Z.-H.; Peng, B.-R.; Huang, L.-C.; Hwang, T.-L.; Sung, P.-J. New 11,20-Epoxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae). Molecules 2019, 24, 2487.
Lin C-C, Su J-H, Chen W-F, Wen Z-H, Peng B-R, Huang L-C, Hwang T-L, Sung P-J. New 11,20-Epoxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae). Molecules. 2019; 24(13):2487.
Lin, Chia-Cheng; Su, Jui-Hsin; Chen, Wu-Fu; Wen, Zhi-Hong; Peng, Bo-Rong; Huang, Lin-Cyuan; Hwang, Tsong-Long; Sung, Ping-Jyun. 2019. "New 11,20-Epoxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae)." Molecules 24, no. 13: 2487.
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