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Open AccessReview

Chemical Structures and Pharmacological Profiles of Ginseng Saponins

School of Biological Sciences, University of Hong Kong, Pok Fu Lam Road, Hong Kong SAR, China
State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China
Author to whom correspondence should be addressed.
Academic Editor: David Popovich
Molecules 2019, 24(13), 2443;
Received: 31 May 2019 / Revised: 28 June 2019 / Accepted: 1 July 2019 / Published: 3 July 2019
(This article belongs to the Special Issue Saponins)
PDF [1098 KB, uploaded 3 July 2019]
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Ginseng is a group of cosmopolitan plants with more than a dozen species belonging to the genus Panax in the family Araliaceae that has a long history of use in traditional Chinese medicine (TCM). Among the bioactive constituents extracted from ginseng, ginseng saponins are a group of natural steroid glycosides and triterpene saponins found exclusively throughout the plant. Studies have shown that these ginseng saponins play a significant role in exerting multiple therapeutic effects. This review covers their chemical structure and classification, as well as their pharmacological activities, including their regulatory effects on immunomodulation, their anticancer effects, and their functions in the central nervous and cardiovascular systems. The general benefits of ginseng saponins for boosting physical vitality and improving quality of life are also discussed. The review concludes with fruitful directions for future research in the use of ginseng saponins as effective therapeutic agents. View Full-Text
Keywords: ginseng saponins; chemical structure; pharmacological action ginseng saponins; chemical structure; pharmacological action

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Shi, Z.-Y.; Zeng, J.-Z.; Wong, A.S.T. Chemical Structures and Pharmacological Profiles of Ginseng Saponins. Molecules 2019, 24, 2443.

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