Next Article in Journal
Effect of Potassium Sorbate and Ultrasonic Treatment on the Properties of Fish Scale Collagen/Polyvinyl Alcohol Composite Film
Next Article in Special Issue
Role of Some Food-Grade Synthesized Flavonoids on the Control of Ochratoxin A in Aspergillus carbonarius
Previous Article in Journal
Influence of Different Drying Techniques on Phenolic Compounds, Antioxidant Capacity and Colour of Ziziphus jujube Mill. Fruits
Previous Article in Special Issue
Interaction of Dihydrocitrinone with Native and Chemically Modified Cyclodextrins
Open AccessReview

Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action

by Ilya Lyagin 1,2 and Elena Efremenko 1,2,*
1
Faculty of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia
2
Emanuel Institute of Biochemical Physics, RAS, Moscow 119334, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Molecules 2019, 24(13), 2362; https://doi.org/10.3390/molecules24132362
Received: 29 May 2019 / Revised: 14 June 2019 / Accepted: 24 June 2019 / Published: 26 June 2019
(This article belongs to the Special Issue Mycotoxins)
Mycotoxins are highly dangerous natural compounds produced by various fungi. Enzymatic transformation seems to be the most promising method for detoxification of mycotoxins. This review summarizes current information on enzymes of different classes to convert various mycotoxins. An in-depth analysis of 11 key enzyme mechanisms towards dozens of major mycotoxins was realized. Additionally, molecular docking of mycotoxins to enzymes’ active centers was carried out to clarify some of these catalytic mechanisms. Analyzing protein homologues from various organisms (plants, animals, fungi, and bacteria), the prevalence and availability of natural sources of active biocatalysts with a high practical potential is discussed. The importance of multifunctional enzyme combinations for detoxification of mycotoxins is posed. View Full-Text
Keywords: enzyme; mycotoxin; conversion; biochemical mechanism; molecular modeling; origins; detoxification; antidote enzyme; mycotoxin; conversion; biochemical mechanism; molecular modeling; origins; detoxification; antidote
Show Figures

Figure 1

MDPI and ACS Style

Lyagin, I.; Efremenko, E. Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action. Molecules 2019, 24, 2362.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop