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Open AccessArticle

Peppermint Essential Oil-Doped Hydroxyapatite Nanoparticles with Antimicrobial Properties

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Faculty of Horticulture, University of Agronomic Sciences and Veterinary Medicine, 59 Mărăşti Blvd., 011464 Bucharest, Romania
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Multifunctional Materials and Structures Laboratory, National Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, 077125 Magurele, Romania
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Low Temperature Plasma Laboratory, National Institute for Laser, Plasma and Radiation Physics, 409 Atomistilor Street, P.O. Box MG 36, 077125 Magurele, Romania
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Microbiology Department, Faculty of Biology, University of Bucharest, 1–3 Portocalelor Lane, 77206 Bucharest, Romania
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Earth, Environmental and Life Sciences Section, Research Institute of the University of Bucharest (ICUB), 91-95 Splaiul Independentei, 050095 Bucharest, Romania
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Department of Surgery, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari, Sector 5, 050474 Bucharest, Romania
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Emergency Hospital Floreasca Bucharest, 8 Calea Floresca, 014461 Bucharest, Romania
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Author to whom correspondence should be addressed.
Academic Editor: Francesca Mancianti
Molecules 2019, 24(11), 2169; https://doi.org/10.3390/molecules24112169
Received: 30 April 2019 / Revised: 6 June 2019 / Accepted: 6 June 2019 / Published: 9 June 2019
(This article belongs to the Special Issue Biological Activities of Essential Oils)
This study aimed at developing an antimicrobial material based on hydroxyapatite (HAp) and peppermint essential oil (P-EO) in order to stimulate the antimicrobial activity of hydroxyapatite. The molecular spectral features and morphology of the P-EO, HAp and hydroxyapatite coated with peppermint essential oil (HAp-P) were analyzed using Fourier-transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The coating of the HAp with the P-EO did not affect the ellipsoidal shape of the nanoparticles. The overlapping of IR bands of P-EO and HAp in the HAp-P spectrum determined the formation of the broad molecular bands that were observed in the spectral regions of 400–1000 cm−1 and 1000–1200 cm−1. The antibacterial activity of the P-EO, HAp and HAp-P were also tested against different Gram-positive bacteria (methicillin-resistant Staphylococcus aureus (MRSA) 388, S. aureus ATCC 25923, S. aureus ATCC 6538, E. faecium DSM 13590), Gram-negative bacteria (Escherichia coli ATCC 25922, E. coli C5, P. aeruginosa ATCC 27853, P. aeruginosa ATCC 9027) and a fungal strain of Candida parapsilosis. The results of the present study revealed that the antimicrobial activity of HAp-P increased significantly over that of HAp. View Full-Text
Keywords: hydroxyapatite; peppermint essential oil; antimicrobial properties hydroxyapatite; peppermint essential oil; antimicrobial properties
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MDPI and ACS Style

Badea, M.L.; Iconaru, S.L.; Groza, A.; Chifiriuc, M.C.; Beuran, M.; Predoi, D. Peppermint Essential Oil-Doped Hydroxyapatite Nanoparticles with Antimicrobial Properties. Molecules 2019, 24, 2169.

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