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Synthesis and Chemical Properties of 3-Phosphono-coumarins and 1,2-Benzoxaphosphorins as Precursors for Bioactive Compounds

Department of Organic Chemistry and Pharmacognosy, Faculty of Chemistry and Pharmacy, Sofia University “St. Kliment Ohridski”, 1 J. Bouchier Buld., 1164 Sofia, Bulgaria
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Academic Editors: Salvatore Genovese, Serena Fiorito and Vito Alessandro Taddeo
Molecules 2019, 24(11), 2030; https://doi.org/10.3390/molecules24112030
Received: 24 April 2019 / Revised: 23 May 2019 / Accepted: 27 May 2019 / Published: 28 May 2019
(This article belongs to the Special Issue Coumarins and Coumarin Derivatives: From Chemistry to Drug)

Abstract

Coumarins are an important class of natural heterocyclic compounds that have attracted considerable synthetic and pharmacological interest due to their various biological activities. This review emphasizes on the synthetic methods for the preparation of dialkyl 2-oxo-2H-1-benzo- pyran-3-phosphonates and alkyl 1,2-benzoxaphosphorin-3-carboxylates. Their chemical properties as acceptors in conjugate addition reactions, [2+2] and [3+2] cycloaddition reactions are discussed. View Full-Text
Keywords: coumarins; 2-oxo-2H-1-benzopyrans; 2-oxo-2H-chromenes; 1,2-bezoxaphosphorines; 1,2-bezoxaphosphorines-3-phosphonic acid; 1,2-phosphorinines; conjugate addition; [2+2] cycloaddition; [3+2] cycloaddition coumarins; 2-oxo-2H-1-benzopyrans; 2-oxo-2H-chromenes; 1,2-bezoxaphosphorines; 1,2-bezoxaphosphorines-3-phosphonic acid; 1,2-phosphorinines; conjugate addition; [2+2] cycloaddition; [3+2] cycloaddition
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Koleva, A.I.; Petkova-Yankova, N.I.; Nikolova, R.D. Synthesis and Chemical Properties of 3-Phosphono-coumarins and 1,2-Benzoxaphosphorins as Precursors for Bioactive Compounds. Molecules 2019, 24, 2030.

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