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Keywords = 1,2-phosphorinines

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38 pages, 11682 KB  
Review
Synthesis and Chemical Properties of 3-Phosphono-coumarins and 1,2-Benzoxaphosphorins as Precursors for Bioactive Compounds
by Ana I. Koleva, Nevena I. Petkova-Yankova and Rositca D. Nikolova
Molecules 2019, 24(11), 2030; https://doi.org/10.3390/molecules24112030 - 28 May 2019
Cited by 23 | Viewed by 6499
Abstract
Coumarins are an important class of natural heterocyclic compounds that have attracted considerable synthetic and pharmacological interest due to their various biological activities. This review emphasizes on the synthetic methods for the preparation of dialkyl 2-oxo-2H-1-benzo- pyran-3-phosphonates and alkyl 1,2-benzoxaphosphorin-3-carboxylates. Their [...] Read more.
Coumarins are an important class of natural heterocyclic compounds that have attracted considerable synthetic and pharmacological interest due to their various biological activities. This review emphasizes on the synthetic methods for the preparation of dialkyl 2-oxo-2H-1-benzo- pyran-3-phosphonates and alkyl 1,2-benzoxaphosphorin-3-carboxylates. Their chemical properties as acceptors in conjugate addition reactions, [2+2] and [3+2] cycloaddition reactions are discussed. Full article
(This article belongs to the Special Issue Coumarins and Coumarin Derivatives: From Chemistry to Drug)
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