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Open AccessArticle

Insecticidal Activity of Four Lignans Isolated from Phryma leptostachya

by 1,2, 1,2, 1,2, 1,2, 1,2, 1,2,3, 2,4 and 1,2,5,*
1
Institute of Pesticide Science, College of Plant Protection, Northwest A & F University, Yangling, Shaanxi 712100, China
2
Key Laboratory for Botanical Pesticide R & D of Shaanxi Province, Yangling, Shaanxi 712100, China
3
Plant Protection Department, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt
4
College of Chemistry & Pharmacy, Northwest A & F University, Yangling, Shaanxi 712100, China
5
Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau, Ministry of Agriculture, Yangling, Shaanxi 712100, China
*
Author to whom correspondence should be addressed.
Academic Editor: Francesco Epifano
Molecules 2019, 24(10), 1976; https://doi.org/10.3390/molecules24101976
Received: 5 May 2019 / Revised: 19 May 2019 / Accepted: 20 May 2019 / Published: 22 May 2019
(This article belongs to the Special Issue Natural Product Isolation, Identification and Biological Activity)
A new lignan (T4) and three known lignans (T1, T2, and T3) were isolated from the methanol extract of the roots of Phryma leptostachya using bioassay-guided method, and their structures were identified as phrymarolin I (T1), II (T2), haedoxan A (T3), and methyl 4-((6a-acetoxy-4-(6-methoxybenzo[d][1,3]dioxol-5-yl)tetrahydro-1H,3H-furo[3,4–c]furan-1-yl)oxy)-1-hydroxy-2,2-dimethoxy-5-oxocyclopent-3-ene-1-carboxylate (T4) byNMR and ESI-MS spectral data. Bioassay results revealed that haedoxan A exhibited remarkably high insecticidal activity against Mythimna separata with a stomach toxicity LC50 value of 17.06 mg/L and a topical toxicity LC50 value of 1123.14 mg/L at 24 h, respectively. Phrymarolin I and compound T4 also showed some stomach toxicity against M. separata with KD50 values of 3450.21 mg/L at 4 h and 2807.10 mg/L at 8 h, respectively. In addition, phrymarolin I and haedoxan A exhibited some stomach toxicity against Plutella xylostella with an LC50 value of 1432.05 and 857.28 mg/L at 48 h, respectively. In conclusion, this study demonstrated that lignans from P. leptostachya are promising as a novel class of insecticides or insecticide lead compounds for developing botanical pesticides. View Full-Text
Keywords: lignans; Phryma leptostachya; insecticidal activity; Mythimna separata; Plutella xylostella lignans; Phryma leptostachya; insecticidal activity; Mythimna separata; Plutella xylostella
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MDPI and ACS Style

Li, Y.; Wei, J.; Fang, J.; Lv, W.; Ji, Y.; Aioub, A.A.; Zhang, J.; Hu, Z. Insecticidal Activity of Four Lignans Isolated from Phryma leptostachya. Molecules 2019, 24, 1976.

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