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Molecules 2018, 23(9), 2342; https://doi.org/10.3390/molecules23092342

Anti-Inflammatory and Skin-Moisturizing Effects of a Flavonoid Glycoside Extracted from the Aquatic Plant Nymphoides indica in Human Keratinocytes

1
Skin Science Research Institute, Kolmar Korea Co., Ltd., Chungcheongbukdo 28116, Korea
2
Traditional Korean Medicine Technology Division, National Development Institute of Korean Medicine, Gyeongsangbuk-do 38540, Korea
*
Author to whom correspondence should be addressed.
Received: 6 August 2018 / Revised: 7 September 2018 / Accepted: 11 September 2018 / Published: 13 September 2018
(This article belongs to the Special Issue Anti-Inflammatory Activity of Natural Products)
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Abstract

Nymphoides indica, an aquatic plant, is used as folk medicine in some countries. Our previous study demonstrated that the methanol extract of N. indica inhibited the activity of tyrosinases, tyrosine related protein (TRP)1 and TRP2, and microphthalmia-associated transcription factor, as well as the activity of protein kinase A, by effectively inhibiting cyclic adenosine monophosphate. Although the biological activities of N. indica extract have been reported, there are no reports on the skin bioactivity of the main compound(s) on human keratinocytes. This study investigated the anti-inflammatory and moisturizing effects of quercetin 3,7-dimethyl ether 4′-glucoside (QDG) isolated from N. indica. In brief, ultraviolet B irradiated keratinocytes were pretreated with different concentrations of QDG, and the effects of QDG on various inflammatory markers were determined. QDG significantly inhibited inflammation-related cytokines and chemokines and enhanced the activation of skin barrier factors. Additionally, QDG also attenuated phosphorylation inhibition of the upstream cytokines and nuclear factor-κB expression. These results suggest that QDG isolated from N. indica may serve as a potential source of bioactive substances for chronic inflammatory skin diseases. View Full-Text
Keywords: quercetin 3,7-dimethyl ether 4′-glucoside; Nymphoides indica; anti-inflammatory; skin moisturizing quercetin 3,7-dimethyl ether 4′-glucoside; Nymphoides indica; anti-inflammatory; skin moisturizing
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Kim, Y.A.; Kim, D.H.; Park, C.B.; Park, T.S.; Park, B.J. Anti-Inflammatory and Skin-Moisturizing Effects of a Flavonoid Glycoside Extracted from the Aquatic Plant Nymphoides indica in Human Keratinocytes. Molecules 2018, 23, 2342.

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