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Molecules 2018, 23(9), 2273; https://doi.org/10.3390/molecules23092273

A Phytochemical-Based Copolymer Derived from Coriolus versicolor Polysaccharopeptides for Gene Delivery

1
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China
2
School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen 518060, China
3
Academy of Medical Science, Zhengzhou University, Zhengzhou 450001, China
4
Department of Chemistry, Zhejiang University, Hangzhou 310058, China
*
Authors to whom correspondence should be addressed.
Received: 11 July 2018 / Revised: 23 July 2018 / Accepted: 3 August 2018 / Published: 6 September 2018
(This article belongs to the Special Issue Molecules for Biotechnologies)
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Abstract

Coriolus versicolor is an herb widely used for cancer treatment in traditional Chinese medicine. Its active ingredients, polysaccharopeptides (PSP), have been used for adjuvant therapies in cancer treatment. This study conjugates Coriolus versicolor PSP with poly(ethylenimine) (PEI) to generate a PSP-PEI copolymer for gene transfer. After PEI conjugation, both the pH buffering capacity and DNA compaction ability of PSP are significantly increased. Compared with that of PSP, the transfection efficiency of PSP-PEI is 10 to 20-fold higher in vitro. This is a proof-of-concept study reporting the direct use of bioactive phytochemicals from traditional Chinese medicine for gene vector development. The promising performance of PSP-PEI raises the possibility that bioactive herbal ingredients can be further developed as a multi-therapeutic gene carrier for tackling cancers. View Full-Text
Keywords: Coriolus versicolor; herbs; gene delivery; poly(ethylenimine); polysaccharopeptide Coriolus versicolor; herbs; gene delivery; poly(ethylenimine); polysaccharopeptide
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Lai, W.-F.; Lin, M.C.; Tang, G. A Phytochemical-Based Copolymer Derived from Coriolus versicolor Polysaccharopeptides for Gene Delivery. Molecules 2018, 23, 2273.

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