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Review

ELF3, ELF5, EHF and SPDEF Transcription Factors in Tissue Homeostasis and Cancer

by 1,2,†, 1,2,† and 1,2,*
1
Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria 3084, Australia
2
School of Cancer Medicine, La Trobe University, Bundoora, Victoria 3086, Australia
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Takaomi Sanda
Molecules 2018, 23(9), 2191; https://doi.org/10.3390/molecules23092191
Received: 15 August 2018 / Revised: 23 August 2018 / Accepted: 23 August 2018 / Published: 30 August 2018
(This article belongs to the Special Issue Transcription Factors as Therapeutic Targets)
The epithelium-specific ETS (ESE) transcription factors (ELF3, ELF5, EHF and SPDEF) are defined by their highly conserved ETS DNA binding domain and predominant epithelial-specific expression profile. ESE transcription factors maintain normal cell homeostasis and differentiation of a number of epithelial tissues, and their genetic alteration and deregulated expression has been linked to the progression of several epithelial cancers. Herein we review the normal function of the ESE transcription factors, the mechanisms by which they are dysregulated in cancers, and the current evidence for their role in cancer progression. Finally, we discuss potential therapeutic strategies for targeting or reactivating these factors as a novel means of cancer treatment. View Full-Text
Keywords: ELF3; ELF5; EHF; SPDEF; transcription factor; cancer ELF3; ELF5; EHF; SPDEF; transcription factor; cancer
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MDPI and ACS Style

Luk, I.Y.; Reehorst, C.M.; Mariadason, J.M. ELF3, ELF5, EHF and SPDEF Transcription Factors in Tissue Homeostasis and Cancer. Molecules 2018, 23, 2191. https://doi.org/10.3390/molecules23092191

AMA Style

Luk IY, Reehorst CM, Mariadason JM. ELF3, ELF5, EHF and SPDEF Transcription Factors in Tissue Homeostasis and Cancer. Molecules. 2018; 23(9):2191. https://doi.org/10.3390/molecules23092191

Chicago/Turabian Style

Luk, Ian Y., Camilla M. Reehorst, and John M. Mariadason 2018. "ELF3, ELF5, EHF and SPDEF Transcription Factors in Tissue Homeostasis and Cancer" Molecules 23, no. 9: 2191. https://doi.org/10.3390/molecules23092191

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