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Molecules 2018, 23(8), 1885;

Lignin-Derived Biomaterials for Drug Release and Tissue Engineering

Department of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, von-Liebig-Str. 20, D-53359 Rheinbach, Germany
Faculty of Environment and Natural Sciences, Brandenburg University of Technology BTU Cottbus-Senftenberg, Platz der Deutschen Einheit 1, D-03046 Cottbus, Germany
Rheinische Friedrich-Wilhelms-University Bonn, INRES, Klein-Altendorf 2, D-53359 Rheinbach, Germany
Kompetenzzentrum Holz GmbH, Altenberger Strasse 69, A-4040 Linz, Austria
Rheinische Friedrich Wilhelms-University Bonn, Katzenburgweg 7-9, D-53115 Bonn, Germany
Author to whom correspondence should be addressed.
Academic Editors: Charles Xu and Michael Paleologou
Received: 6 July 2018 / Revised: 23 July 2018 / Accepted: 24 July 2018 / Published: 27 July 2018
(This article belongs to the Special Issue Lignin for Energy, Chemicals and Materials)
Full-Text   |   PDF [3424 KB, uploaded 30 July 2018]   |  


Renewable resources are gaining increasing interest as a source for environmentally benign biomaterials, such as drug encapsulation/release compounds, and scaffolds for tissue engineering in regenerative medicine. Being the second largest naturally abundant polymer, the interest in lignin valorization for biomedical utilization is rapidly growing. Depending on its resource and isolation procedure, lignin shows specific antioxidant and antimicrobial activity. Today, efforts in research and industry are directed toward lignin utilization as a renewable macromolecular building block for the preparation of polymeric drug encapsulation and scaffold materials. Within the last five years, remarkable progress has been made in isolation, functionalization and modification of lignin and lignin-derived compounds. However, the literature so far mainly focuses lignin-derived fuels, lubricants and resins. The purpose of this review is to summarize the current state of the art and to highlight the most important results in the field of lignin-based materials for potential use in biomedicine (reported in 2014–2018). Special focus is placed on lignin-derived nanomaterials for drug encapsulation and release as well as lignin hybrid materials used as scaffolds for guided bone regeneration in stem cell-based therapies. View Full-Text
Keywords: biomaterial; bone regeneration; drug release; hydrogel; lignin; multivariate data processing; osteogenesis; scaffolds; stem cells; tissue engineering biomaterial; bone regeneration; drug release; hydrogel; lignin; multivariate data processing; osteogenesis; scaffolds; stem cells; tissue engineering

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Witzler, M.; Alzagameem, A.; Bergs, M.; Khaldi-Hansen, B.E.; Klein, S.E.; Hielscher, D.; Kamm, B.; Kreyenschmidt, J.; Tobiasch, E.; Schulze, M. Lignin-Derived Biomaterials for Drug Release and Tissue Engineering. Molecules 2018, 23, 1885.

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