14 MeV Neutrons for 99Mo/99mTc Production: Experiments, Simulations and Perspectives
AbstractBackground: the gamma-emitting radionuclide Technetium-99m (99mTc) is still the workhorse of Single Photon Emission Computed Tomography (SPECT) as it is used worldwide for the diagnosis of a variety of phatological conditions. 99mTc is obtained from 99Mo/99mTc generators as pertechnetate ion, which is the ubiquitous starting material for the preparation of 99mTc radiopharmaceuticals. 99Mo in such generators is currently produced in nuclear fission reactors as a by-product of 235U fission. Here we investigated an alternative route for the production of 99Mo by irradiating a natural metallic molybdenum powder using a 14-MeV accelerator-driven neutron source. Methods: after irradiation, an efficient isolation and purification of the final 99mTc-pertechnetate was carried out by means of solvent extraction. Monte Carlo simulations allowed reliable predictions of 99Mo production rates for a newly designed 14-MeV neutron source (New Sorgentina Fusion Source). Results: in traceable metrological conditions, a level of radionuclidic purity consistent with accepted pharmaceutical quality standards, was achieved. Conclusions: we showed that this source, featuring a nominal neutron emission rate of about 1015 s−1, may potentially supply an appreciable fraction of the current 99Mo global demand. This study highlights that a robust and viable solution, alternative to nuclear fission reactors, can be accomplished to secure the long-term supply of 99Mo. View Full-Text
Share & Cite This Article
Capogni, M.; Pietropaolo, A.; Quintieri, L.; Angelone, M.; Boschi, A.; Capone, M.; Cherubini, N.; De Felice, P.; Dodaro, A.; Duatti, A.; Fazio, A.; Loreti, S.; Martini, P.; Pagano, G.; Pasquali, M.; Pillon, M.; Uccelli, L.; Pizzuto, A. 14 MeV Neutrons for 99Mo/99mTc Production: Experiments, Simulations and Perspectives. Molecules 2018, 23, 1872.
Capogni M, Pietropaolo A, Quintieri L, Angelone M, Boschi A, Capone M, Cherubini N, De Felice P, Dodaro A, Duatti A, Fazio A, Loreti S, Martini P, Pagano G, Pasquali M, Pillon M, Uccelli L, Pizzuto A. 14 MeV Neutrons for 99Mo/99mTc Production: Experiments, Simulations and Perspectives. Molecules. 2018; 23(8):1872.Chicago/Turabian Style
Capogni, Marco; Pietropaolo, Antonino; Quintieri, Lina; Angelone, Maurizio; Boschi, Alessandra; Capone, Mauro; Cherubini, Nadia; De Felice, Pierino; Dodaro, Alessandro; Duatti, Adriano; Fazio, Aldo; Loreti, Stefano; Martini, Petra; Pagano, Guglielmo; Pasquali, Micol; Pillon, Mario; Uccelli, Licia; Pizzuto, Aldo. 2018. "14 MeV Neutrons for 99Mo/99mTc Production: Experiments, Simulations and Perspectives." Molecules 23, no. 8: 1872.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.