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Molecules 2018, 23(7), 1799; https://doi.org/10.3390/molecules23071799

Induction of Different Sensitization Patterns of MRSA to Antibiotics Using Electroporation

1
Institute of High Magnetic Fields, Vilnius Gediminas Technical University, Naugarduko st. 41, 03227 Vilnius, Lithuania
2
Laboratory of Biodeterioration Research, Nature Research Centre, Akademijos st. 2, 08412 Vilnius, Lithuania
3
Laboratory of Microbiology of the Centre of Laboratory Medicine, Vilnius University Hospital Santariškių Clinics, Santariskiu g. 2, 08406 Vilnius, Lithuania
4
Laboratory of Mycology, Nature Research Centre, Žaliųjų ežerų st. 49, 08406 Vilnius, Lithuania
5
Department of Microbiology and Biotechnology, Vilnius University, Sauletekio al. 7, 10257 Vilnius, Lithuania
6
State Research Institute Centre for Innovative Medicine, Department of Immunology, Santariškių st. 5, 08406 Vilnius, Lithuania
*
Author to whom correspondence should be addressed.
Received: 25 June 2018 / Revised: 18 July 2018 / Accepted: 20 July 2018 / Published: 20 July 2018
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Abstract

Treatment of bacteria-associated infections is complicated and antibiotic treatment alone is often inadequate to overcome biofilm infections. Physical methods allow overcoming this problem and propose solutions that are non-dependent on drug resistance. In this work, we investigated the feasibility of pulsed electric fields for sensitization of MRSA to common antibiotics. We analyzed the efficacy of inactivation of methicillin-resistant Staphylococcus aureus in 5–20 kV/cm electric field separately and in combination with gentamicin, doxycycline, ciprofloxacin, sulfamethoxazole, and vancomycin. Combined treatment allowed using up to 1000-fold smaller concentrations of antibiotics to induce the same inactivation of S. aureus. View Full-Text
Keywords: antibiotics; electric field; drug resistance; membrane permeabilization; S. aureus antibiotics; electric field; drug resistance; membrane permeabilization; S. aureus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Novickij, V.; Švedienė, J.; Paškevičius, A.; Markovskaja, S.; Lastauskienė, E.; Zinkevičienė, A.; Girkontaitė, I.; Novickij, J. Induction of Different Sensitization Patterns of MRSA to Antibiotics Using Electroporation. Molecules 2018, 23, 1799.

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