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Open AccessReview

Molecules that Inhibit Bacterial Resistance Enzymes

by Yuan Liu 1,2, Ruichao Li 1,2, Xia Xiao 1,2 and Zhiqiang Wang 1,2,*
1
Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
2
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China
*
Author to whom correspondence should be addressed.
Academic Editor: Peter J. Rutledge
Molecules 2019, 24(1), 43; https://doi.org/10.3390/molecules24010043
Received: 20 November 2018 / Revised: 18 December 2018 / Accepted: 19 December 2018 / Published: 22 December 2018
Antibiotic resistance mediated by bacterial enzymes constitutes an unmet clinical challenge for public health, particularly for those currently used antibiotics that are recognized as “last-resort” defense against multidrug-resistant (MDR) bacteria. Inhibitors of resistance enzymes offer an alternative strategy to counter this threat. The combination of inhibitors and antibiotics could effectively prolong the lifespan of clinically relevant antibiotics and minimize the impact and emergence of resistance. In this review, we first provide a brief overview of antibiotic resistance mechanism by bacterial secreted enzymes. Furthermore, we summarize the potential inhibitors that sabotage these resistance pathways and restore the bactericidal activity of inactive antibiotics. Finally, the faced challenges and an outlook for the development of more effective and safer resistance enzyme inhibitors are discussed. View Full-Text
Keywords: antibiotic resistance; bacterial enzymes; molecules; therapeutic potential antibiotic resistance; bacterial enzymes; molecules; therapeutic potential
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MDPI and ACS Style

Liu, Y.; Li, R.; Xiao, X.; Wang, Z. Molecules that Inhibit Bacterial Resistance Enzymes. Molecules 2019, 24, 43.

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