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Molecules 2018, 23(7), 1786;

Dietary Polyphenols and Periodontitis—A Mini-Review of Literature

Department of Kinesiology and Nutrition Sciences, School of Allied Health Sciences, University of Nevada Las Vegas, 4505 S Maryland Parkway, Las Vegas, NV 89154, USA
Department of Biomedical Sciences, School of Dental Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA
Author to whom correspondence should be addressed.
Academic Editor: Margarida Castell Escuer
Received: 10 June 2018 / Revised: 14 July 2018 / Accepted: 18 July 2018 / Published: 20 July 2018
(This article belongs to the Special Issue Natural Polyphenols and Health)
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Periodontitis, which is a chronic infection and disease of the periodontium, is a significant global health burden and is linked to other chronic health conditions such as diabetes and cardiovascular diseases. Dietary polyphenols present in a wide variety of plant-based foods, herbs, and botanicals have been shown to exert antimicrobial, anti-inflammatory, and reduced osteoclast and alveolar bone loss activities in animal models of periodontitis. Polyphenol-containing beverages and foods especially green tea and its active catechin epigallocatechin-3-gallate, cranberries, pomegranates, and fruit and vegetable extracts have reported bacteriostatic/bactericidal activity against microbial species such as P. gingivalis and shown total bacterial burden in clinical studies. These polyphenols also exhibit anti-inflammatory and antioxidant effects, which have the potential to impact various biological mechanisms for reducing the initiation and progression of periodontitis. The main objective of this mini-review is to focus on the mechanisms of action of dietary polyphenols in improving the pathophysiology underlying chronic inflammatory diseases like periodontitis based on pre-clinical and clinical models. View Full-Text
Keywords: periodontitis; polyphenols; green tea; inflammation; P. gingivalis periodontitis; polyphenols; green tea; inflammation; P. gingivalis

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Basu, A.; Masek, E.; Ebersole, J.L. Dietary Polyphenols and Periodontitis—A Mini-Review of Literature. Molecules 2018, 23, 1786.

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