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Molecules 2018, 23(7), 1786; https://doi.org/10.3390/molecules23071786

Dietary Polyphenols and Periodontitis—A Mini-Review of Literature

1
Department of Kinesiology and Nutrition Sciences, School of Allied Health Sciences, University of Nevada Las Vegas, 4505 S Maryland Parkway, Las Vegas, NV 89154, USA
2
Department of Biomedical Sciences, School of Dental Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Margarida Castell Escuer
Received: 10 June 2018 / Revised: 14 July 2018 / Accepted: 18 July 2018 / Published: 20 July 2018
(This article belongs to the Special Issue Natural Polyphenols and Health)
Full-Text   |   PDF [4282 KB, uploaded 20 July 2018]   |  

Abstract

Periodontitis, which is a chronic infection and disease of the periodontium, is a significant global health burden and is linked to other chronic health conditions such as diabetes and cardiovascular diseases. Dietary polyphenols present in a wide variety of plant-based foods, herbs, and botanicals have been shown to exert antimicrobial, anti-inflammatory, and reduced osteoclast and alveolar bone loss activities in animal models of periodontitis. Polyphenol-containing beverages and foods especially green tea and its active catechin epigallocatechin-3-gallate, cranberries, pomegranates, and fruit and vegetable extracts have reported bacteriostatic/bactericidal activity against microbial species such as P. gingivalis and shown total bacterial burden in clinical studies. These polyphenols also exhibit anti-inflammatory and antioxidant effects, which have the potential to impact various biological mechanisms for reducing the initiation and progression of periodontitis. The main objective of this mini-review is to focus on the mechanisms of action of dietary polyphenols in improving the pathophysiology underlying chronic inflammatory diseases like periodontitis based on pre-clinical and clinical models. View Full-Text
Keywords: periodontitis; polyphenols; green tea; inflammation; P. gingivalis periodontitis; polyphenols; green tea; inflammation; P. gingivalis
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Basu, A.; Masek, E.; Ebersole, J.L. Dietary Polyphenols and Periodontitis—A Mini-Review of Literature. Molecules 2018, 23, 1786.

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