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Molecules 2018, 23(7), 1725; https://doi.org/10.3390/molecules23071725

Construction of Thermo-Responsive Elastin-Like Polypeptides (ELPs)-Aggregation-Induced-Emission (AIE) Conjugates for Temperature Sensing

1
Faculty of Health Sciences, University of Macau, Taipa 999078, Macau, China
2
Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China
3
Department of Biotechnology and Bioengineering, Huaqiao University, Xiamen 361021, China
*
Authors to whom correspondence should be addressed.
Received: 10 June 2018 / Revised: 11 July 2018 / Accepted: 12 July 2018 / Published: 14 July 2018
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Abstract

In this work, an aggregation-induced emission (AIE) molecule (tetraphenylethene derivative, TPE-COOH) was conjugated to elastin-like polypeptides (ELPs40) via an amide bond to form ELPs40-TPE. The successful synthesis of ELPs40-TPE was confirmed by Circular Dichroism spectroscopy, gel electrophoresis, UV-vis absorption, and fluorescence emission spectroscopy. ELPs40-TPE possessed both amphiphilicity and the features of an AIE, and the fluorescence intensity was dependent on the local temperature. The Hela cells imaging indicated that ELPs40-TPE has great potential for bio-imaging applications because of its advantages of high fluorescence intensity, good water-solubility, and remarkable biocompatibility. View Full-Text
Keywords: elastin-like polypeptides (ELPs); aggregation-induced-emission (AIE); thermo-responsive; temperature sensing elastin-like polypeptides (ELPs); aggregation-induced-emission (AIE); thermo-responsive; temperature sensing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chen, Z.; Ding, Z.; Zhang, G.; Tian, L.; Zhang, X. Construction of Thermo-Responsive Elastin-Like Polypeptides (ELPs)-Aggregation-Induced-Emission (AIE) Conjugates for Temperature Sensing. Molecules 2018, 23, 1725.

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